Results 121 to 130 of about 837,485 (313)

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Economic Activity and Atmospheric Pollution in Spain: An Input-Output Approach [PDF]

, 2008
[eng] In this study we analyse some aspects of the interdependences between the economy and the environment by applying the input-output approach. Although economic activity affects the environment in many ways, in this study we only focus on one: the ...
Serrano Gutiérrez, Mònica, Serrano, Mònica (Serrano Gutiérrez)   +1 more
core  

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Examining the effect of farm and farmers' characteristics and input allocation on potato production

Frontiers in Sustainable Food Systems
The objective of this research was to examine the effects of farm and farmers' characteristics, and input allocation on potato production in Gowa Regency, South Sulawesi Province, Indonesia, using binary logistic regression.
Ardi Rumallang, Ardi Rumallang, Muslim Salam, Letty Fudjaja, Pipi Diansari, Baharuddin Patandjengi, Rahim Darma, A. Nixia Tenriawaru, Heliawaty, Akhsan, Rahmadanih, Rida Akzar, Muhammad Ridwan, Hamed Noralla Bakheet Ali   +13 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

ANALYSES OF THE RELATIONSHIP BETWEEN EXCHANGE RATES AND EMPLOYMENT IN KOREA [PDF]

Previous studies about relationship between exchange rates and employment focus on only developed countries. But country characteristics in developing countries are different from those of developed countries.
Wanjoong Kim
core  

STATIONARY STOCHASTIC INPUT FLOW MODELING OF BRANCHED CONVEYOR SYSTEMS

Сучасні інформаційні системи
The object of research is stochastic stationary input material flow of a conveyor-type transport system. Subject of research is a method for generating realizations of a stationary stochastic input flow of material on the basis of experimental data. The
Oleh Pihnastyi , Victoriya Usik , Anna Burduk   +2 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Input random processes of chemical-engineering objects simulation

Тонкие химические технологии, 2006
It is revealed, that consideration of chemical-engineering objects’ random components of input and output characteristics enables to determine more subtle characteristics of their operation.
V. I. Bozhko
doaj