Results 101 to 110 of about 3,049,647 (303)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Comparative Analysis of Input Image Characteristics in Convolutional Neural Network-based Signature Detection [PDF]
RadioengineeringThe detection of malware represents a primary concern in contemporary computer security and is therefore imperative for the protection of systems and data integrity.
M. Adamec, M. Turcanik
doaj
Agriculture’s contribution to rural viability: An approach to estimate regional economic impacts of agricultural policy in Swiss case study regions [PDF]
This paper develops a thorough yet easily implementable approach to measuring agriculture’s contribution to rural viability. The approach is based on input-output modelling.
Flury, Christian +2 more
core +1 more source
Homeostatic plasticity and external input shape neural network dynamics
, 2018 In vitro and in vivo spiking activity clearly differ. Whereas networks in vitro develop strong bursts separated by periods of very little spiking activity, in vivo cortical networks show continuous activity.
Priesemann, Viola +2 more
core +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
The Characteristics of Low-Input Grasslands
, 2012 Several studies show that the global interest in health and human nutrition is continually growing. A continuous change includes also the food production systems. There are more and more papers that connect the value of agricultural production and food production system, papers that show a particular interes on the high value of products that are ...
Bogdan, Anca Dorina +9 more
openaire +1 more source
Towards Simulating Humans in Augmented Multi-party Interaction [PDF]
, 2005 Human-computer interaction requires modeling of the user. A user profile typically contains preferences, interests, characteristics, and interaction behavior.
Nijholt, Anton
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source