Results 111 to 120 of about 837,485 (313)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Capital as a Factor of Production in OECD Agriculture: Measurement and Data [PDF]
This paper provides a farm sector comparison of levels of capital input for fourteen OECD countries for the period 1973-2002. The starting point for construction of a measure of capital input is the measurement of capital stock.
Mesonada, Carlos San Juan +3 more
core +1 more source
Light attenuation characteristics of glacially-fed lakes [PDF]
, 2014 Transparency is a fundamental characteristic of aquatic ecosystems and is highly responsive to changes in climate and land use. The transparency of glacially-fed lakes may be a particularly sensitive sentinel characteristic of these changes.
Olson, MH +8 more
core +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
CONSTRUCTING GENERATORS OF VALUES OF AN INPUT MATERIAL FLOW OF CONVEYOR-TYPE TRANSPORT SYSTEMS
Сучасні інформаційні системиObject of research is stochastic stationary input flow of material of a conveyor-type transport system. Subject of research is development of a method for generating a training data set for a neural network in a transport conveyor model.
Oleh Pihnastyi +2 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Autism and Developmental Language ImpairmentsCaregiver language input is a key component of children's early developmental environment, with its nature likely varying based on certain characteristics.
Yijie Li +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Modification of Computer-Aided Modelling Input Data Based on Medium-Scale Fire Tests of Wooden Beams
BioResourcesThe aim of the paper was to optimize the settings of the material properties of a computer model describing heat transfer in a wooden beam exposed to thermal loading from a porcelain radiation panel.
Dominik Spilak +5 more
doaj