Results 111 to 120 of about 3,049,647 (303)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

CONSTRUCTING GENERATORS OF VALUES OF AN INPUT MATERIAL FLOW OF CONVEYOR-TYPE TRANSPORT SYSTEMS

Сучасні інформаційні системи
Object of research is stochastic stationary input flow of material of a conveyor-type transport system. Subject of research is development of a method for generating a training data set for a neural network in a transport conveyor model.
Oleh Pihnastyi , Georgii Kozhevnikov , Anna Burduk   +2 more
doaj   +1 more source

Voltage-Mode Multifunction Biquadratic Filters Using New Ultra-Low-Power Differential Difference Current Conveyors [PDF]

, 2013
This paper presents two low-power voltage-mode multifunction biquadratic filters using differential difference current conveyors. Each proposed circuit employs three differential difference current conveyors, two grounded capacitors and two grounded ...
Dejhan, K., Khateb, F., Kumngern, M., Phasukkit, P., Tungjitkusolmun, S.   +4 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Modification of Computer-Aided Modelling Input Data Based on Medium-Scale Fire Tests of Wooden Beams

BioResources
The aim of the paper was to optimize the settings of the material properties of a computer model describing heat transfer in a wooden beam exposed to thermal loading from a porcelain radiation panel.
Dominik Spilak, Katarina Dubravska, Andrea Majlingova, Cong Jin, Qiang Xu, Lin Jiang   +5 more
doaj  

Caregiver Language Input in Different Engagement States During Play Interactions With Toddlers With Autism: An Observational Study

Autism and Developmental Language Impairments
Caregiver language input is a key component of children's early developmental environment, with its nature likely varying based on certain characteristics.
Yijie Li, Shaoli Lv, Linru Liu, Leran Xue, Huishi Huang, Yu Xing, Qianying Ye, Feixia Zhang, Hongzhu Deng   +8 more
doaj   +1 more source

EXPLAINING OUTPUT GROWTH WITH A HETEROSCEDASTIC NON-NEUTRAL PRODUCTION FRONTIER: THE CASE OF SHEEP FARMS IN GREECE [PDF]

This paper extends the primal decomposition of TFP changes to the case of non-neutral production frontiers. Output growth is decomposed into input growth (size effect), changes in technical efficiency, technical change, and the effect of returns to scale.
Giannis Karagiannis, Vangelis Tzouvelekas   +1 more
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source