Results 91 to 100 of about 837,485 (313)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
HEDONIC PRICE ESTIMATION FOR KANSAS WHEAT CHARACTERISTICS [PDF]
A hedonic price model is applied to a cross-sectional time-series data set of Kansas wheat characteristics. Results indicate that prices received by wheat producers reflect the presence of conventional quality characteristics of wheat and also milling ...
Goodwin, Barry K., Espinosa, Juan Andres
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Identification of Regional Fundamental Economic Structure (FES) of India: An Input-Output and Field of Influence Approach [PDF]
This study provides an understanding of the Indian regional economy utilizing the fundamental economic structure (FES) approach. The FES construct implies that selected characteristics of an economy will vary predictably with region size, as measured by ...
Thakur, Sudhir K.
core
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Seismic input characterization for some sites in Italy [PDF]
, 2014 The seismic input characterization is the first task in the analysis of the seismic behaviour of a structure. The definition of the seismogenetic sources, earthquake catalogue and site characteristics are preliminary to the study.
Rinaldis D., Clemente P.
core
Sharp Switching Characteristics of Single Electron Transistor with Discretized Charge Input [PDF]
, 2016 For the low-power consumption analog and digital circuit applications based on a single-electron transistor, enhancement of its switching performance is required.
Yoshinao Mizugaki +2 more
core +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Taxing Sweets: Sweetener Input Tax or Final Consumption Tax? [PDF]
In order to reduce obesity and associated costs, policymakers are considering various policies, including taxes, to change consumers’ high-calorie consumption habits.
Miao, Zhen +2 more
core +1 more source