Results 101 to 110 of about 3,243,734 (347)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Input parameters and scenarios, including economic inputs

open access: yes, 2012
Geographical locations of the farms are the core in these models. We used geographical data, number of animals and specification of herd types for the 50,853 herds in the Danish Husbandry Register (CHR) in 2007. For each herd, the daily probability of moving animals, to another herd or to the abattoir, was calculated as the sum of all registered ...
Boklund, Anette   +1 more
openaire   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

open access: yesFEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas   +6 more
wiley   +1 more source

The Sensitivity of the Input Impedance Parameters of Track Circuits to Changes in the Parameters of the Track

open access: yesAdvances in Electrical and Electronic Engineering, 2017
This paper deals with the sensitivity of the input impedance of an open track circuit in the event that the parameters of the track are changed. Weather conditions and the state of pollution are the most common reasons for parameter changes.
Lubomir Ivanek   +3 more
doaj   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

open access: yesFEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava   +3 more
wiley   +1 more source

Adaptive Control Design for Arneodo Chaotic System with Uncertain Parameters and Input Saturation

open access: yesAdvances in Mathematical Physics, 2020
In this paper, tracking controller and synchronization controller of the Arneodo chaotic system with uncertain parameters and input saturation are considered. An adaptive tracking control law and an adaptive synchronization control law are proposed based
Chunhua Cheng   +4 more
doaj   +1 more source

Inverse Uncertainty Quantification using the Modular Bayesian Approach based on Gaussian Process, Part 2: Application to TRACE

open access: yes, 2018
Inverse Uncertainty Quantification (UQ) is a process to quantify the uncertainties in random input parameters while achieving consistency between code simulations and physical observations. In this paper, we performed inverse UQ using an improved modular
Kozlowski, Tomasz   +3 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

ptimization the Parameters of Magnetic Abrasive Process Using Taguchi Method to Improve the Surface Roughness

open access: yesAl-Khawarizmi Engineering Journal, 2017
Magnetic abrasive finishing (MAF) process is one of non-traditional or advanced finishing methods which is suitable for different materials and produces high quality level of surface finish where it uses magnetic force as a machining pressure.
Shakir M Mousa
doaj   +1 more source

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