Results 61 to 70 of about 3,243,734 (347)

Gain control network conditions in early sensory coding [PDF]

, 2013
Gain control is essential for the proper function of any sensory system. However, the precise mechanisms for achieving effective gain control in the brain are unknown.
A Couto, A Destexhe, AF Silbering, AF Silbering, B Haider, Brian H. Smith, BW Strowbridge, C Buckley, CC Girardin, CI Bargmann, CJP Vicente, CM Root, Cv Vreeswijk, D Dominguez, DA McCormick, E Av-Ron, E Salinas, EA Hallem, EA Hallem, Eduardo Serrano, F Locatelli, GA Wright, GC Turner, H Belmabrouk, H Breer, HR Wilson, I Ito, IP Sudhakaran, J Huang, J Perez-Orive, JJ Hopfield, K Touhara, LF Abbott, M Bazhenov, M García-Sanchez, M Ng, M Papadopoulou, M Rabinovich, M Schmuker, M Stopfer, M Yokoi, N Yamagata, O Shriki, Olaf Sporns, P Anderson, P Szyszka, R Huerta, R Huerta, R Huerta, Rafael Levi, Ramón Huerta, RI Wilson, RI Wilson, S Das, S Grossberg, S Krofczik, S Sachse, Si Amari, SR Olsen, SR Olsen, SR Olsen, T Nowotny, TA Cleland, TA Cleland, Thomas Nowotny, TP Vogels, V Bhandawat, Y Shang   +67 more
core   +5 more sources

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

NUFT USNT Thermal Input Parameters [PDF]

, 2000
This document describes the thermal input parameters required to run the USNT module of the NUFT code. The USNT module handles multi-component transport of multiple fluid phases and heat through porous and fractured media. The thermal input parameters required to model the heat transport by conduction, convection, and radiation are summarized, and the ...
openaire   +2 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Drastic oscillation of peierls stress from peierls-nabarro model calculation and its remedy

Journal of Materials Research and Technology, 2023
Peierls stress (τp) of face-centered-cubic (FCC) structures from the Peierls-Nabarro (PN) model calculation is extremely sensitive to the input parameters including the shear modulus (μ), Poisson's ratio (ν) and generalized stacking fault energy (GSFE ...
Xue-Chun Zhang, Shuo Cao, Rui Yang, Qing-Miao Hu   +3 more
doaj   +1 more source

Parameter setting and input reduction

, 2008
The language acquisition procedure identifies certain properties of the target grammar before others. The evidence from the input is processed in a stepwise order. Section 1 equates that order and its typical effects with an order of parameter setting.
Arnold Ernest Evers, Jacqueline van Kampen   +1 more
openaire   +3 more sources

A simple method of constructing binary black hole initial data [PDF]

, 2017
By applying a parabolic-hyperbolic formulation of the constraints and superposing Kerr-Schild black holes, a simple method is introduced to initialize time evolution of binary systems. As the input parameters are essentially the same as those used in the
Rácz, István
core   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The choice of input parameters adaptive systems processing of experimental data

Adaptivni Sistemi Avtomatičnogo Upravlinnâ, 2019
Optimization of the adaptive system of processing of experimental data is taken to the receipt of analytical dependences for objective functions (for example, errors of measuring); to being of correlations for the tasks of optimization; decision-making ...
I. Miroshnichenko, O. Zalevskaya
doaj   +1 more source