Results 51 to 60 of about 291,863 (292)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

“Serbian land” in the Tărnovо inscription of John Asen II in the light of the political and geographical terminology of the time [PDF]

open access: yesZbornik Radova Vizantološkog Instituta
This study examines the notion of friendship depicted in the epistolary corpus of Euthymios Malakes who served as bishop of Neai Patrai during the second half of the twelfth century.
Komatina Ivana, Komatina Predrag
doaj   +1 more source

Collaborative practices using computers and the internet in science classrooms. [PDF]

open access: yes, 2011
Investigations that allow for students to self-direct their inquiries in science classrooms involve building on existing understanding, problem solving and reasoning.
Cowie, Bronwen   +2 more
core   +2 more sources

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

open access: yesFEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti   +3 more
wiley   +1 more source

The Passing of Print [PDF]

open access: yes, 2011
This paper argues that ephemera is a key instrument of cultural memory, marking the things intended to be forgotten. This important role means that when ephemera survives, whether accidentally or deliberately, it does so despite itself. These survivals,
Beagrie Neil   +20 more
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

“Who of us has never traced light over these walls”?: The archaeology of Stanisław Grochowiak’s poems

open access: yesActa Universitatis Lodziensis. Folia Litteraria Polonica, 2020
Through a simple wall, a transparent element of everyday life, Stanisław Grochowiak’s poems enable one to uncover the existential concrete element, matter endowed with an amazing hypnagogic potential, a chronicle of ‘objectness’.
Helena Hejman
doaj   +1 more source

A Reassessment of the Urban Context of the Republican Baths (VIII 5, 36) [PDF]

open access: yes, 2018
Das Foro Triangolare wird gewöhnlich als Ort eines athletischmilitärischen Komplexes im späthellenistischen Samnitischen Pompeji identifiziert. Benennung (gymnasium, campus, palaestra der vereiia) und Ausdehnung sind zwar umstritten, aber die ...
Trümper, Monika
core   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

open access: yesFEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim   +11 more
wiley   +1 more source

Pierres & inscriptions

open access: yes, 2020
Parmi les sources indiennes anciennes, qu’elles soient épigraphiques ou archéologiques, on peut souvent distinguer sources royales et non royales (ou locales), sources publiques et privées. Dans de nombreux cas, le royal semble avoir le statut d’archétype, inventé d’abord pour des usages royaux, puis adopté et adapté par des acteurs autres que royaux ...
openaire   +2 more sources

Home - About - Disclaimer - Privacy