Results 141 to 150 of about 1,079,259 (346)

Advances in Microfluidic Cochlea‐On‐A‐Chip

open access: yesAdvanced Science, EarlyView.
This review systematically examines diverse cell sources for inner ear organoids and outlines stepwise induction protocols. Furthermore, it discusses current applications and prospective developments of cochlea‐on‐a‐chip technologies in areas such as deafness modeling, mechanistic studies, and drug evaluation, with particular focus on gene‐therapy drug
Tian Shen   +10 more
wiley   +1 more source

Listerin Alleviates Alzheimer's Disease through IRE1‐mediated Decay of TLR4 mRNA

open access: yesAdvanced Science, EarlyView.
Alzheimer's disease (AD) progression is influenced by microglia‐mediated neuroinflammation. Here, it is demonstrated that Listerin suppresses neuroinflammatory signaling and cognitive impairment in AD models by triggering IRE1α‐mediated TLR4 mRNA decay. Adenoviral Listerin delivery reduces amyloid‐β pathology, positioning it as a new therapeutic target.
Fei Qin   +9 more
wiley   +1 more source

Impact of Changes in U.S. Grain Standards on Discounts for Insects in Stored Grain [PDF]

open access: yes
The Federal Grain Inspection Service changed U.S. grain standards in 1988. Insect discounts given at country elevators and at terminal elevators were analyzed to determine impacts of the new standards.
Duncan, Steven S.   +3 more
core   +1 more source

Finite element approach to trap-insect model [PDF]

open access: yes, 2015
The trap-insect model considered in this presentation comprises a system of two advection-diffusion-reaction equations. We develop finite element approximation of the solution of the model in order to produce accurate numerical simulations using a non ...
Anguelov, Roumen   +2 more
core  

Gentle Label‐Free Nonlinear Optical Imaging Relaxes Linear‐Absorption‐Mediated Triplet

open access: yesAdvanced Science, EarlyView.
The phototoxicity in nonlinear optical microscopy arises mainly from linear absorption of intrinsic biomolecules rather than nonlinear absorption. This mechanism is supported by a reproducible phototoxicity assay based on widely available chicken breast.
Geng Wang   +4 more
wiley   +1 more source

Engineering Escherichia coli for high-yielding 2,5-Dimethylpyrazine synthesis from L-Threonine by reconstructing metabolic pathways and enhancing cofactors regeneration

open access: yesBiotechnology for Biofuels and Bioproducts
2,5-Dimethylpyrazine (2,5-DMP) is important pharmaceutical raw material and food flavoring agent. Recently, engineering microbes to produce 2,5-DMP has become an attractive alternative to chemical synthesis approach.
Xin-Xin Liu   +10 more
doaj   +1 more source

Insect diversity and composition during the wet and dry seasons in three forest types of Johor, Malaysia [PDF]

open access: yes, 2015
The insect diversity and abundance in three forest types namely: Endau Rompin (pristine lowland forest) Gunung Ledang (pristine highland forest) and Bukit Soga (degraded lowland forest) in Johor, Malaysia were studied.
Siddiki, Aishatu
core  

Enhancing Specificity, Precision, Accessibility, Flexibility, and Safety to Overcome Traditional CRISPR/Cas Editing Challenges and Shape Future Innovations

open access: yesAdvanced Science, EarlyView.
CRISPR/Cas9, while transformative, faces challenges in specificity, precision, delivery, accessibility, flexibility, and safety. This review addresses these limitations by highlighting strategies to reduce off‐target effects, exploring HDR‐based and alternative editing approaches, and evaluating advanced delivery mechanisms.
Muna Alariqi   +8 more
wiley   +1 more source

Managing Economic Risk from Invasive Species: Bug Options [PDF]

open access: yes
Invasive insect species cause billions of dollars of direct and indirect damage to U.S. crops each year. The market for insuring insect damage is, however, far from complete.
Eaves, James   +3 more
core   +1 more source

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