Results 91 to 100 of about 2,005,171 (322)
Human Schlafen 14 Cleavage of Short Double‐Stranded RNAs Underpins its Antiviral Activity
Advanced Science, EarlyView.SLFN14 is associated with human diseases. SLFN14 is found to cleave RNAs containing short duplexes. The cryo‐EM structures of SLFN14 and SLFN14‐hairpin RNA complex reveal that SLFN14 assembles into a ring‐like dimer; two RNase domains form an RNA‐binding groove accommodating a hairpin RNA.
Mengyun Li +8 more
wiley +1 more source
Scientific Reports, 2017 Anopheles mosquitoes are vectors of the human malaria parasite, Plasmodium falciparum. The vector microbiota is a likely factor influencing parasite transmission.
Eugeni Belda +7 more
doaj +1 more source
, 2017 Xylella fastidiosa is a bacterial plant pathogen that causes Pierce’s disease of grape, citrus variegated chlorosis, phony peach disease, alfalfa dwarf, and leaf scorch of plum, blueberry, and pecan in the southern United States.
L. Overall, E. Rebek
semanticscholar +1 more source
Invasive mutualisms between a plant pathogen and insect vectors in the Middle East and Brazil
Royal Society Open Science, 2016 Complex multi-trophic interactions in vectorborne diseases limit our understanding and ability to predict outbreaks. Arthropod-vectored pathogens are especially problematic, with the potential for novel interspecific interactions during invasions ...
R. B. Queiróz +6 more
semanticscholar +1 more source
Peptide‐Based Biomaterials as a Promising Tool for Cancer Radiotherapy
Advanced Science, EarlyView.This review provides a systematic overview of peptide‐based biomaterials in tumor radiotherapy, covering their roles as both radiosensitizers and radiopharmaceuticals. Peptide‐based radiosensitizers are generally divided into three categories: peptides as direct radiosensitizers, peptides as carriers of radiosensitizers, and targeted‐peptide‐modified ...
Qian Wang, Xinhui Chu, Jianfeng Liu
wiley +1 more source
PathogensHoneybees (Apis mellifera) are pollinating agents of economic importance. The role of the gut microbiome in honeybee health has become increasingly evident due to its relationship with immune function, growth, and development.
Abdulkadir Yusif Maigoro +4 more
doaj +1 more source
, 2017 Many biotic and abiotic factors contribute to the onset of oak decline. Among biotic agents, a variety of fungi and insects cause extensive disease and insect outbreaks in oak forests.
T. Panzavolta +7 more
semanticscholar +1 more source
Scientific Reports, 2016 Monochamus beetles are the dispersing vectors of the nematode Bursaphelenchus xylophilus, the causative agent of pine wilt disease (PWD). PWD inflicts significant damages in Eurasian pine forests. Symbiotic microorganisms have a large influence in insect
M. Alves +10 more
semanticscholar +1 more source
A Complementarity‐Based Approach to De Novo Binder Design
Advanced Science, EarlyView.A novel method for surface complementarity detection (HECTOR) enables highly efficient docking and design of protein interfaces. Applied to therapeutically relevant targets, this method yields de novo binders with potent antagonistic activity. As a first‐principles approach, HECTOR offers a training‐free solution to the binder design problem and is ...
Kateryna Maksymenko +17 more
wiley +1 more source
STING COPII ER Export Trafficking and Signaling Primed by Phosphorylation Switches
Advanced Science, EarlyView.This schematic outlines STING trafficking and signaling via coat protein II (COPII)‐mediated endoplasmic reticulum (ER) export. Following cyclic GMP‐AMP (cGAMP) stimulation, TANK‐binding kinase 1 (TBK1) activates on COPII vesicles, partially dissociating into the cytosol to phosphorylate ER‐localized STING, creating pSGME/pFS COPII‐sorting motifs ...
Yanan Nan +10 more
wiley +1 more source