Results 101 to 110 of about 715,619 (300)

OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD

Advanced Science, EarlyView.
This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li, Jingyue Song, Kaili Ma, Shunan Tang, Shuqian Wang, Wenya Ji, Chen Lu, Ting Zhang, Huaping Zheng, Xiaowei Zheng, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

Site‐Specific Protein Bioconjugation Through Cellular Incorporation of Noncanonical Amino Acids

Angewandte Chemie, EarlyView.
Genetic code expansion (GCE) enables site‐specific installation of noncanonical amino acids containing bioorthogonal conjugation handles, allowing precise, homogeneous protein modification. This review examines the principles of orthogonal translation, surveys the chemistries available for chemoselective labeling, and highlights emerging multi‐site ...
Rahul Sarkar, Manas Joshi, Abhishek Chatterjee   +2 more
wiley   +2 more sources

Potential risk of re-emergence of urban transmission of Yellow Fever virus in Brazil facilitated by competent Aedes populations

Scientific Reports, 2017
Yellow fever virus (YFV) causing a deadly viral disease is transmitted by the bite of infected mosquitoes. In Brazil, YFV is restricted to a forest cycle maintained between non-human primates and forest-canopy mosquitoes, where humans can be tangentially
Dinair Couto-Lima, Yoann Madec, Maria Ignez Bersot, Stephanie Silva Campos, Monique de Albuquerque Motta, Flávia Barreto dos Santos, Marie Vazeille, Pedro Fernando da Costa Vasconcelos, Ricardo Lourenço-de-Oliveira, Anna-Bella Failloux   +9 more
doaj   +1 more source

Insect Vectors of Oak Wilt Fungus

Journal of Economic Entomology, 1953
Uploaded by Plazi for TaxoDros. We do not have abstracts.
Griswold, C.L., Neiswander, R.B.
openaire   +2 more sources

Improvement of colony management in insect mass‐rearing for sterile insect technique applications

Sterile Insect Technique (SIT) applications against major insect pests and disease vectors rely on the cost-effective production of high-quality sterile males.
Haymer, David, Mastrangelo, Thiago, Tsiamis, George, Segura, Diego F., Malacrida, Anna R., Liedo, Pablo, Abd‐Alla, Adly M. M., Jehle, Johannes A., Herrero, Salvador, Njiokou, Flobert, Ramırez‐Santos, Edwin M., Khamis, Fathiya, Pagabeleguem, Soumaïla, Geiger, Anne, Weiss, Brian L., Ros, Vera I. D., Jehle, Johannes, A., Ros, Vera I.D., Ramırez-Santos, Edwin M., Abd-Alla, Adly M.M., Segura, Diego Fernando, Ramirez-Santos, Edwin M., Khamis, Fathiya Mbarak, Malacrida, Anna   +23 more
core   +1 more source

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

Advanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung, Xu Wang, Bin Liu, Raktim Roy, Nancy Jaiswal, Ratan K. Rai, Yuichiro Takagi, Cen Gao, Lifan Zeng, Ho‐Yin Lo, Reagan K. Wohlford, Ryan K. Higgins, Bruce T. Lamb, Anantha Shekhar, Anita C. Bellail, Chunhai Hao   +15 more
wiley   +1 more source

Molecular Basis of NPY Recognition and Ligand Selectivity at the Neuropeptide Y5 Receptor

Angewandte Chemie, EarlyView.
Here, we present the first active structure of the neuropeptide Y5 receptor (NPY5R) in complex with its endogenous ligand NPY and the Gi1 protein. The cryo‐electron microscopy structure, validated by extensive mutagenesis studies, gives important insights into the molecular mechanisms underlying ligand binding and receptor activation.
Lisa Christin Peuker, Hongyu Wang, Kun Chen, Kristin Löbner, Karin Mörl, Simon Jonas Schwarz, Qiang Zhao, Beili Wu, Annette Gabriele Beck‐Sickinger   +8 more
wiley   +2 more sources

Oral Actinomyces Species Exposure is Associated with Anxiety‐Like Behavior, Mitochondrial Remodeling, and Altered GABAergic Pathways

Advanced Science, EarlyView.
Oral exposure to cannabis‐associated Actinomyces species, particularly A. meyeri, is associated with anxiety‐like behavior in mice in the absence of detectable bacterial translocation or overt systemic inflammation. These findings support a potential oral‐brain metabolic axis involving candidate metabolites such as arginine and argininosuccinate ...
Tabinda Salman, Zhenwu Luo, Douglas Johnson, Arshad A. Noorani, Zhuang Wan, Bogdan Bordieanu, Zhi‐wei Ye, Rachel D. Penrod, Hongxu Xian, Sylvia Fitting, Peter W. Kalivas, Wei Jiang   +11 more
wiley   +1 more source

The Anopheles gambiae 2La chromosome inversion is associated with susceptibility to Plasmodium falciparum in Africa

eLife, 2017
Chromosome inversions suppress genetic recombination and establish co-adapted gene complexes, or supergenes. The 2La inversion is a widespread polymorphism in the Anopheles gambiae species complex, the major African mosquito vectors of human malaria ...
Michelle M Riehle, Tullu Bukhari, Awa Gneme, Wamdaogo M Guelbeogo, Boubacar Coulibaly, Abdrahamane Fofana, Adrien Pain, Emmanuel Bischoff, Francois Renaud, Abdoul H Beavogui, Sekou F Traore, N’Fale Sagnon, Kenneth D Vernick   +12 more
doaj   +1 more source

Gapless Complete Genome and Multi‐Omics Illuminate Immune Adaptation and Host‐Virus Interactions in a Coronavirus Reservoir

Advanced Science, EarlyView.
We present a complete T2T genome assembly for a key bat reservoir. Integrating population genomics, comparative genomics, transcriptomics, single‐cell omics, and functional assays, we resolve previously inaccessible genomic regions and identify evolutionary signatures associated with immune adaptation.
Yuting Wang, Sheng Zhang, Linxia Ouyang, Xin Du, Xin Huang, Zhilin Wang, Huixian Xie, Jiale Tang, Liyi Lou, Wenqing Ling, Weihao Wang, Jiang Zhou, Zhen Liu, Yibo Hu, Fuwen Wei, Guangping Huang   +15 more
wiley   +1 more source