Results 1 to 10 of about 11,515,911 (324)

Gene editing of SAMHD1 in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation, HIV-1 restriction, and cellular dNTP levels

mBio, 2023
Sterile α motif and HD domain-containing protein 1 (SAMHD1) is a dNTP triphosphate triphosphohydrolase (dNTPase) and a potent restriction factor for immunodeficiency virus 1 (HIV-1), active in myeloid and resting CD4+ T cells.
Moritz Schüssler, Kerstin Schott, Nina Verena Fuchs, Adrian Oo, Morssal Zahadi, Paula Rauch, Baek Kim, Renate König   +7 more
doaj   +1 more source

Visualizing Pyrazinamide Action by Live Single-Cell Imaging of Phagosome Acidification and Mycobacterium tuberculosis pH Homeostasis

mBio, 2022
Mycobacterium tuberculosis segregates within multiple subcellular niches with different biochemical and biophysical properties that, upon treatment, may impact antibiotic distribution, accumulation, and efficacy.
Pierre Santucci, Beren Aylan, Laure Botella, Elliott M. Bernard, Claudio Bussi, Enrica Pellegrino, Natalia Athanasiadi, Maximiliano G. Gutierrez   +7 more
doaj   +1 more source

Pseudomonas aeruginosa OprF plays a role in resistance to macrophage clearance during acute infection

Scientific Reports, 2021
While considered an extracellular pathogen, Pseudomonas aeruginosa has been reported to be engulfed by macrophages in cellular and animal models. However, the role of macrophages in P. aeruginosa clearance in vivo remains poorly studied.
Malika Moussouni, Laurence Berry, Tamara Sipka, Mai Nguyen-Chi, Anne-Béatrice Blanc-Potard   +4 more
doaj   +1 more source

Antiserum againstXanthomonasphytopathogen inhibits host—Pathogen interaction in seedlings ofBrassica campestris [PDF]

FEMS Microbiology Letters, 1987
Xanthomonas campestris pv campestris (X.c.c.), the causal agent of crucifer black rot, causes turnip seedlings to collapse and rot. X.c. pv vitians (X.c.v.) is a non-pathogen of turnips and triggers a resistance response. Transconjugants of X.c.c., containing defined fragments of DNA from X.c.v., which have reduced pathogenicity to turnips were ...
Ian N. Roberts, J.Maxwell Dow, Keng Yeang Lum, Graham Scofield, Christine E. Barber, Michael J. Daniels   +5 more
openaire   +1 more source

Succession in the caecal microbiota of developing broilers colonised by extended-spectrum β-lactamase-producing Escherichia coli

Animal Microbiome, 2022
Background Broilers are among the most common and dense poultry production systems, where antimicrobials have been used extensively to promote animal health and performance.
Ingrid Cárdenas-Rey, Teresita d. J. Bello Gonzalez, Jeanet van der Goot, Daniela Ceccarelli, Gerwin Bouwhuis, Danielle Schillemans, Stephanie D. Jurburg, Kees T. Veldman, J. Arjan G. M. de Visser, Michael S. M. Brouwer   +9 more
doaj   +1 more source

Micromanipulation of theChlamydia pneumoniaeinclusion: implications for cloning and host–pathogen interactions [PDF]

FEMS Microbiology Letters, 2003
The Chlamydia trachomatis inclusion is fragile, rendering it incompatible to micromanipulation. We show that the Chlamydia pneumoniae inclusion differs, being resistant to micromanipulation as shown by direct microinjection of the infected host cytosol or the inclusion itself. We have used micromanipulation to clone C.
Jens, Gieffers, Van, Tamplin, Matthias, Maass, Robert J, Belland, Harlan D, Caldwell   +4 more
openaire   +2 more sources

High content quantitative imaging of Mycobacterium tuberculosis responses to acidic microenvironments within human macrophages

FEBS Open Bio, 2023
Intracellular pathogens such as Mycobacterium tuberculosis (Mtb) have evolved diverse strategies to counteract macrophage defence mechanisms including phagolysosomal biogenesis.
Beren Aylan, Laure Botella, Maximiliano G. Gutierrez, Pierre Santucci   +3 more
doaj   +1 more source

Invertebrates as animal models forStaphylococcus aureuspathogenesis: a window into host–pathogen interaction [PDF]

FEMS Immunology & Medical Microbiology, 2005
Recently, the use of invertebrate models of infection has given exciting insights into host-pathogen interaction for a number of bacteria. In particular, this has revealed important factors of the host response with remarkable parallels in higher organisms.
Jorge, García-Lara, Andrew J, Needham, Simon J, Foster   +2 more
openaire   +2 more sources

The pursuit of cryptococcal pathogenesis: heterologous hosts and the study of cryptococcal host–pathogen interactions [PDF]

FEMS Yeast Research, 2006
Analysis of the molecular mechanisms by which a pathogen interacts with the human host is most commonly performed using a mammalian model of infection. However, several virulence-related genes previously shown to be involved in mammalian infection with Cryptococcus neoformans have also been shown to play a role in the interaction of these pathogens ...
Roanna, London, Benjamin Samuel, Orozco, Eleftherios, Mylonakis   +2 more
openaire   +2 more sources

Unconventional animal models: a booster for new advances in host—pathogen interactions [PDF]

Frontiers in Cellular and Infection Microbiology, 2014
ANIMALS AS TOOLS Historically, biology has greatly benefited and is still benefiting from the study of animals. A quick search of the PubMed database for “animal models” yields some 41,000 studies, and many others will come. Once regarded as the subject of biological studies [Darwin’s finches are a wellknown example (Peterson, 2008)], animals have ...
Conti, Filippo, Abnave, Prasad, Ghigo, Eric   +2 more
openaire   +3 more sources