Results 41 to 50 of about 197,177 (212)

Discovery and molecular identification of a new orthophasmavirus in the Asian citrus psyllid (Diaphorina citri)

Frontiers in Microbiology
IntroductionAsian citrus psyllid (ACP, Diaphorina citri) is the primary vector of Candidatus Liberibacter asiaticus (CLas), a major causal pathogen of citrus Huanglongbing (HLB). HLB remains difficult to control, and exploring viral genomic resources may
Song Zhang, Song Zhang, Jing Chen, Jing Chen, Luqin Liu, Luqin Liu, Zhipeng Xie, Zhipeng Xie, Jiamei Liang, Jiamei Liang, Fulin Yan, Fulin Yan, Yaqin Song, Xuefeng Wang, Xuefeng Wang, Changyong Zhou, Changyong Zhou, Mengji Cao, Mengji Cao, Jinxiang Liu, Jinxiang Liu   +20 more
doaj   +1 more source

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

Advanced Science, EarlyView.
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun, Junhao Fan, Xiaolu Xie, Yuting Shi, Xiaoqing Liu, Tiefeng Xu, Sidi Yang, Keda Shi, Chengshu Xie, Shixiong Li, Siwen Chen, Ruoxi Cai, Ping He, Yuzhen Ye, Tao Chen, Xiancai Ma, Chunmei Li, Jingyou Yu, Deyin Guo   +18 more
wiley   +1 more source

Insect Vectors of Plant Viruses: Host Interactions, Their Effects, and Future Opportunities

Advances in Agriculture
Plant viruses are endocellular, and they multiply inside their host plant cells. Outside of the host cells, they are acellular and cannot multiply and move to their hosts for reproduction.
Gebissa Yigezu Wendimu, Ashenafi Kassaye Gurmu   +1 more
doaj   +1 more source

Bridging the Structural Gap: A Methodological Review of Cryo-Electron Microscopy for Underrepresented Viruses

Viruses
Cryo-electron microscopy (cryo-EM) has revolutionized structural virology, enabling routine structure determination at 2–4 Å resolution, with exceptional cases reaching 1.56 Å.
Yoon Ho Park, Hyun Suk Jung, Sungjin Moon, Chihong Song   +3 more
doaj   +1 more source

OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD

Advanced Science, EarlyView.
This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li, Jingyue Song, Kaili Ma, Shunan Tang, Shuqian Wang, Wenya Ji, Chen Lu, Ting Zhang, Huaping Zheng, Xiaowei Zheng, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

Advanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung, Xu Wang, Bin Liu, Raktim Roy, Nancy Jaiswal, Ratan K. Rai, Yuichiro Takagi, Cen Gao, Lifan Zeng, Ho‐Yin Lo, Reagan K. Wohlford, Ryan K. Higgins, Bruce T. Lamb, Anantha Shekhar, Anita C. Bellail, Chunhai Hao   +15 more
wiley   +1 more source

Detection of Candidatus Liberibacter asiaticus and five viruses in individual Asian citrus psyllid in China

Frontiers in Plant Science
IntroductionAsian citrus psyllid (ACP, Diaphorina citri) is an important transmission vector of “Candidatus Liberibacter asiaticus” (CLas), the causal agent of Huanglongbing (HLB), the most destructive citrus disease in the world.
Luqin Liu, Jing Chen, Junyao Jiang, Jiamei Liang, Yaqin Song, Qi Chen, Fuling Yan, Ziqin Bai, Zhen Song, Jinxiang Liu   +9 more
doaj   +1 more source

Applications of Proteomic Tools to Study Insect Vector–Plant Virus Interactions

Life, 2020
Proteins are crucial players of biological interactions within and between the organisms and thus it is important to understand the role of proteins in successful partnerships, such as insect vectors and their plant viruses.
Priyanka Mittapelly, Swapna Priya Rajarapu   +1 more
doaj   +1 more source

Molecular Bases and Genetic Design of Rice Disease Resistance for Optimized Yield and Sustainable Agriculture

Advanced Science, EarlyView.
This study integrates rice immune perception, signal transduction, and resistance output into a multi‐omics framework. By combining high‐throughput sequencing, phenomics, and AI‐assisted design with marker‐assisted selection, gene editing, and rapid domestication, we aim to accelerate the precise breeding of disease‐resistant rice varieties by ...
Xinyue Hou, Yuanjiang Cui, Chaoqing Ding, Qian Qian, Deyong Ren   +4 more
wiley   +1 more source

Exploring Virus Diversity in the Potato leafhopper (Empoasca fabae), an Economically Important Agricultural Pest

Viruses
The potato leafhopper (Empoasca fabae, PLH) is a serious pest that feeds on a wide range of agricultural crops and is found throughout the United States but is not known to be a vector for plant-infecting viruses.
Thanuja Thekke-Veetil, Doris Lagos-Kutz, Leslie L. Domier, Nancy K. McCoppin, Glen L. Hartman, Steven J. Clough   +5 more
doaj   +1 more source