Results 51 to 60 of about 742,360 (237)
Viruses, 2014 The HIV-1 subtype C has been substituting the subtype B population in southern Brazil. This phenomenon has been previously described in other countries, suggesting that subtype C may possess greater fitness than other subtypes.
José Boullosa +6 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Hiatus of Vowels and Resolving Them in Central Kurdish [PDF]
مطالعات زبانها و گویشهای غرب ایران, 2019 In this article, the authors have studied the phenomenon of hiatus of vowels and some approaches to resolve it in central Kurdish through descriptive-analytical method and have analyzed collected data in the framework of optimality theory.
Mehran Ahmadi +2 more
doaj
Touch-actuated microneedle array patch for closed-loop transdermal drug delivery
Drug Delivery, 2018 To date, only approximately 20 drugs synthesized with small molecules have been approved by the FDA for use in traditional transdermal patches (TTP) owing to the extremely low permeation rate of the skin barrier for macromolecular drugs.
Jingbo Yang +8 more
doaj +1 more source
Viruses, 2019 The L-protein of vesicular stomatitis virus (VSV) is a single-chain multi-domain RNA-dependent RNA polymerase. Previously reported attempts of intramolecular insertions of fluorescent proteins into the L-protein resulted in temperature-sensitive and ...
Emmanuel Heilmann +7 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Espace populations sociétés, 2004 This paper highlights the role of the French Antilles and Guiana in Caribbean migratory space and focuses on the social insertion of immigrants in the French overseas departments.
Cédric Audebert
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Communication & Professionnalisation, 2019 Le présent article étudie l’hybridation des trajectoires d’insertion professionnelle parmi les nouveaux journalistes de Belgique francophone. Evoluant dans un marché où le volume d’emplois salariés diminue constamment, la majorité des journalistes ...
Olivier Standaert
doaj +1 more source