Laboratory evolution of the bacterial genome structure through insertion sequence activation. [PDF]
Nucleic Acids ResKanai Y +4 more
europepmc +1 more source
Insertion-sequence-mediated mutations both promote and constrain evolvability during a long-term experiment with bacteria. [PDF]
Nat Commun, 2021 Consuegra J +6 more
europepmc +1 more source
Natural Frequencies of Levodopa‐Induced Dyskinesia in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives Abnormal involuntary movements, known as dyskinesias, are common complications of levodopa treatment in patients with Parkinson's disease and can significantly impair quality of life. The underlying pathophysiology remains unclear, and current therapeutic options are limited.
Ioannis U. Isaias +3 more
wiley +1 more source
ST11 carbapenem-resistant Klebsiella pneumoniae integrates virulence plasmid fragments into the chromosome via insertion sequence. [PDF]
BMC MicrobiolLiu X, Xu L, Dong H, Qin S, Li Y, Yao H.
europepmc +1 more source
Insertion Sequence (IS) Element-Mediated Activating Mutations of the Cryptic Aromatic β-Glucoside Utilization (BglGFB) Operon Are Promoted by the Anti-Terminator Protein (BglG) in Escherichia coli. [PDF]
Int J Mol Sci, 2022 Zhang Z, Zhou K, Tran D, Saier M.
europepmc +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Treatment of disorders of consciousness (DoC) remains a major clinical challenge, and noninvasive, targeted modulation of deep brain structures has emerged as a promising therapeutic strategy. We aimed to evaluate the feasibility/safety and preliminary effects of thalamic temporal interference stimulation (TIS) targeting centromedian‐
Gengyao Hu +7 more
wiley +1 more source
Screw Angulation and Insertion Sequence Increase Interfragmentary Compression When Using Plates for Midfoot Arthrodesis: Foam-Surrogate and Cadaveric Validation. [PDF]
Foot Ankle OrthopJohnson J +9 more
europepmc +1 more source
Insertion Sequence (IS)-Excision Enhancer (IEE)-Mediated IS Excision from the <i>lacZ</i> Gene Restores the Lactose Utilization Defect of Shiga Toxin-Producing Escherichia coli O121:H19 Strains and Is Responsible for Their Delayed Lactose Utilization Phenotype. [PDF]
Appl Environ Microbiol, 2022 Nakamura K +5 more
europepmc +1 more source
Arterial Spin‐Labeling MRI at the Cortical‐CSF Interface: A Novel Biomarker in Alzheimer Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background/Objective Arterial spin‐labeling (ASL) MRI can measure perfusion signal adjacent to CSF spaces and may provide information regarding CSF‐adjacent water transport physiology. We developed an automated pipeline to extract cortical‐CSF interface (IF) perfusion for comparison between Alzheimer disease (AD) and cognitively normal ...
Mona Asghariahmadabad +22 more
wiley +1 more source
The ISPpu9 insertion sequence of Pseudomonas putida KT2440 generates various circular intermediates enabling modular transposition. [PDF]
Nucleic Acids ResParés-Guillén E +3 more
europepmc +1 more source