Results 211 to 220 of about 45,101 (293)
Molecular Oral Microbiology, Volume 41, Issue 2, Page 69-84, April 2026.We report optimization of the Treponema denticola shuttle plasmid system by minimizing its size and by characterizing an array of promoter‐gene constructs for genetic complementation, including the first use in Treponema of a Tet‐inducible system for controlled expression of potentially toxic genes.
M. Paula Goetting‐Minesky +8 more
wiley +1 more source
Insertional mutagenesis in a HER2-positive breast cancer model reveals ERAS as a driver of cancer and therapy resistance. [PDF]
Oncogene, 2018 Ikink GJ +8 more
europepmc +1 more source
Identification of novel genes in the carotenogenic and oleaginous yeast Rhodotorula toruloides through genome-wide insertional mutagenesis. [PDF]
BMC Microbiol, 2018 Liu Y +5 more
europepmc +1 more source
Plant Biotechnology Journal, Volume 24, Issue 4, Page 2092-2104, April 2026.ABSTRACT The CRISPR/Cas9 gene‐editing technology has been widely used in defining gene functions and crop improvement. However, some genes are essential for plant growth and development. Loss‐of‐function homozygous mutations in essential genes lead to plant death or sterility.
Meilian Xu +9 more
wiley +1 more source
Identifying tumor promoting genomic alterations in tumor-associated fibroblasts via retrovirus-insertional mutagenesis. [PDF]
Oncotarget, 2017 Rong L +10 more
europepmc +1 more source
Plant Biotechnology Journal, Volume 24, Issue 4, Page 2685-2697, April 2026.ABSTRACT Cannabinoids, such as tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA) and cannabichromenic acid (CBCA), are bioactive and medicinally relevant compounds found in the cannabis plant (Cannabis sativa L.). These three compounds are synthesised from a single precursor, cannabigerolic acid (CBGA), through regioselective reactions ...
Cloé Villard +5 more
wiley +1 more source
Cas9‐Embedding Hyperactive TadA8e Confers Efficient and Highly Specific A‐To‐G Base Editing in Rice
Plant Biotechnology Journal, Volume 24, Issue 4, Page 2576-2591, April 2026.ABSTRACT Adenine base editors (ABEs) produce precise A‐to‐G conversion in the genomic target sites without causing double‐strand breaks. However, the hyperactive adenosine deaminase TadA8e raises safety concerns on genome‐wide off‐target edits. We engineered 11 chimeric proteins for ABEs (CP‐ABEs) by embedding hyperactive TadA8e within Cas9 nickase to ...
Jianjian Hu +14 more
wiley +1 more source
Retroviral insertional mutagenesis implicates E3 ubiquitin ligase RNF168 in the control of cell proliferation and survival. [PDF]
Biosci Rep, 2017 Kizilors A +9 more
europepmc +1 more source
TaRIP2 Positively Regulates Wheat Pollen Wall Formation Through MYB80‐Controlled Lipid Metabolism
Plant Biotechnology Journal, Volume 24, Issue 4, Page 2595-2606, April 2026.ABSTRACT Male‐sterile genes and mutants are critical for hybrid seed production in monocotyledonous crops. Lipids are essential structural components of male reproductive organs, such as the anther and pollen. Here, we show that the pollen‐preferential gene TaRIP2 is essential for wheat anther development and pollen formation. RT‐qPCR analysis revealed
Ran Han +14 more
wiley +1 more source
FEBS Letters, Volume 600, Issue 6, Page 910-938, March 2026.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source