Results 91 to 100 of about 2,746,237 (260)
Epistemic Insight Poster: Can Science & Technology Make Us Fitter
, 2022 Epistemic Insight Poster: Can Science & Technology Make Us ...
LASAR Centre (Learning about Science and Religion)
core +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
, 2020 This is an online course in experimentation as a method of the empirical social sciences, directed at science newcomers and undergrads. We cover topics such as: How do we know what’s true? How can one recognize false conclusions?
Rahal, Rima-Maria
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
AFQ-Insight: statistical learning with tractometry data
, 2020 AFQ-Insight is a Python library for statistical learning with tractometry ...
Narayan, Manjari +2 more
core +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Drift-driven collaborative learning for non-stationary time series: a COVID-19 case study
Journal of Information and TelecommunicationAccurate forecasting of non-stationary time series, such as pandemic data, is particularly challenging due to the presence of concept drifts, i.e. changes in the underlying data-generating process over time.
Khaled Jouini +2 more
doaj +1 more source
Demographics : an expert's insight on the issue in Arizona [PDF]
, 2013 : Arizona's diverse population is always changing. Understanding the state's shifting demographics matters for good planning and effective policy making.
core
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source