Results 71 to 80 of about 2,234,074 (317)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Perspectives Canada: Volume IV Number 1 Winter 1995
, 2019 Perspectives Canada, Vol.IV No.1, is based on the results of 1,200 interviews conducted with a representative sample of Canadian adults between the dates of February 11 and 22, 1995.
Insight Canada Research
core +1 more source
BMC Medical Research MethodologyBackground Population-adjusted indirect comparison using parametric Simulated Treatment Comparison (STC) has had limited application to survival outcomes in unanchored settings.
Christopher G. Fawsitt +4 more
doaj +1 more source
IEEE AccessRetrieval-Augmented Generation (RAG) has gained significant attention from many researchers as an effective solution to address the hallucination issue of Foundational Models (FMs), particularly Large Language Models (LLMs). Although the RAG framework is
Majjed Al-Qatf +7 more
doaj +1 more source
The Computer Journal, 1972 Charles Babbage, who first had the idea of building an automatic computer, died exactly 100 years ago, almost to the day. The first stored program electronic computers began operating in the late 1940s. At that time the late Professor Hartree predicted that a single machine of the same modest size as the EDSAC machine then under construction at ...
openaire +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Perspectives Canada: Volume II Number 2 Spring 1993
, 2019 Perspectives Canada, Vol.II No.2, is based on the results of 1,100 interviews conducted with a representative sample of Canadian adults between the dates of May 2 and 9, 1993.
Insight Canada Research
core +1 more source
Smallholders download and share videos from the Internet to learn about sustainable agriculture
International Journal of Agricultural Sustainability, 2019 Of 1,211 farmers and their representatives registered on www.accessagriculture.org, 142 participated in an on-line survey in November 2017, designed to learn farmer’s opinions of Access Agriculture, an NGO which hosts a digital platform where anyone can ...
Jeffery W. Bentley +4 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Perspectives Canada: Volume IV Number 3 Summer 1995
, 2019 Perspectives Canada, Vol.IV No.3, is based on the results of 1,200 interviews conducted with a representative sample of Canadian adults between the dates of August 1 and 5, 1995. A national sample of this size provides confidence that the survey results
Insight Canada Research
core +1 more source