Results 51 to 60 of about 1,430,196 (268)
Recent Neurobiological Insights into the Concept of Insight in Psychosis
Indian Journal of Psychological Medicine, 2016 The concept of insight in psychosis has been an interesting area in clinical psychiatry for well over a century with a surge in research interest over the past 25 years. Moreover, the past 5 years have been particularly fruitful in deciphering its neurobiological underpinnings.
Starlin Vijay Mythri, Y Sanjay
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
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The Plant GenomeAlfalfa (Medicago sativa L.) is a globally vital forage crop valued for its perennial growth and multiple annual harvests. A breeding effort is underway to improve the crop for productivity and persistence against biotic and abiotic stresses using ...
Alexander M. Sandercock +11 more
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
BMC Medical Research MethodologyBackground Population-adjusted indirect comparison using parametric Simulated Treatment Comparison (STC) has had limited application to survival outcomes in unanchored settings.
Christopher G. Fawsitt +4 more
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Deutsches Ärzteblatt international, 2014 Introducing, the authors explain that based on evidence from studies, theophylline is of little benefit in COPD and associated with risks. At the same time, they state that the interesting question cannot be clarified “conclusively” with their study so that “further … studies of routine data are needed”.
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Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
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IEEE AccessRetrieval-Augmented Generation (RAG) has gained significant attention from many researchers as an effective solution to address the hallucination issue of Foundational Models (FMs), particularly Large Language Models (LLMs). Although the RAG framework is
Majjed Al-Qatf +7 more
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Indian Journal of Psychological Medicine, 2015 Byline: M. Reddy "Amongst the unclarities which are of utmost clinical importance and which cause utmost confusion is the term INSIGHT." -Zilboorg (1952) Good outcome demands better adherence, one essential prerequisite being good insight! Insight is an important and crucial dimension in clinical psychiatry as a component of phenomenology and clinical ...
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