Results 61 to 70 of about 1,430,196 (268)

Insight, Not Numbers [PDF]

open access: yesThe Computer Journal, 1972
Charles Babbage, who first had the idea of building an automatic computer, died exactly 100 years ago, almost to the day. The first stored program electronic computers began operating in the late 1940s. At that time the late Professor Hartree predicted that a single machine of the same modest size as the EDSAC machine then under construction at ...
openaire   +1 more source

Biophysical approaches for studying viral entry

open access: yesFEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Smallholders download and share videos from the Internet to learn about sustainable agriculture

open access: yesInternational Journal of Agricultural Sustainability, 2019
Of 1,211 farmers and their representatives registered on www.accessagriculture.org, 142 participated in an on-line survey in November 2017, designed to learn farmer’s opinions of Access Agriculture, an NGO which hosts a digital platform where anyone can ...
Jeffery W. Bentley   +4 more
doaj   +1 more source

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

open access: yesFEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Associations between cognitive and personality traits and work productivity loss in desk workers with low back pain: a cross-sectional study

open access: yesEnvironmental and Occupational Health Practice
Objectives: This study investigated the associations between cognitive and personality traits and work productivity loss among desk workers with low back pain (LBP). Methods: A cross-sectional study was conducted among 2,223 corporate employees in Japan.
Takahiro Miki   +2 more
doaj   +1 more source

Sistemas dinámicos y teoría de la probabilidad aplicados al diagnóstico de la dinámica cardiaca en dieciséis horas

open access: yesRevista Colombiana de Cardiología, 2020
Resumen: Introducción: se han establecido diagnósticos cuantitativos de los sistemas cardiacos, partiendo de teorías como los sistemas dinámicos, la geometría fractal y la teoría de probabilidad.
Javier Rodríguez   +7 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

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