Results 101 to 110 of about 3,987,444 (239)
The risk of sleep-related death in an inclined sleep environment
BMC Public HealthBackground Unsafe sleep environments are the primary modifiable risk factor for sudden unexpected infant death (SUID). Despite this knowledge, products that deviate from the American Academy of Pediatrics (AAP) safe sleep recommendations continue to be ...
Laura R. Sangaré +4 more
doaj +1 more source
Insight into atmospheres of extrasolar planets through plasma processes
, 2017 Extrasolar planets appear in a chemical diversity unseen in our own solar system. Despite their atmospheres being cold, continuous and transient plasma processes do affect these atmosphere where clouds form with great efficiency.
Helling, Ch., Vorgul, I.
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Current Biology, 2009 SummaryA new book highlights the lessons from nineteenth-century bug collectors. Nigel Williams reports.
openaire +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
BMC Medical Research MethodologyBackground and objectives The National Institute for Health and Care Excellence (England’s health technology assessment body) recommend the use of the average treatment effect (ATE) as an estimand for economic evaluations.
Danilo Di Maio +4 more
doaj +1 more source
Dissecting the quasar main sequence: insight from host galaxy properties
, 2015 The diverse properties of broad-line quasars appear to follow a well-defined main sequence along which the optical FeII strength increases. It has been suggested that this sequence is mainly driven by the Eddington ratio (L/L_Edd) of the black hole (BH ...
Shen, Yue, Sun, Jiayi
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source