Results 101 to 110 of about 5,219,627 (290)

Sarbanes-Oxley\u27s Insight: The Role of Distrust [PDF]

open access: yes, 2008
El presente trabajo tiene por objetivo analizar la regulación aplicable a la inversión extranjera en la Argentina en el período 1853-2007. Su alcance no se limitará a normas de nivel internacional o nacional, por el contrario una de las razones que ...
Perrone, Nicolás Marcelo, Tussie, Diana
core   +1 more source

Superconformal symmetry and higher-derivative Lagrangians

open access: yes, 2013
Superconformal methods are useful to build invariant actions in supergravity. We have a good insight in the possibilities of actions that are at most quadratic in spacetime derivatives, but insight in general higher-derivative actions is missing ...
Van Proeyen, Antoine
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

The risk of sleep-related death in an inclined sleep environment

open access: yesBMC Public Health
Background Unsafe sleep environments are the primary modifiable risk factor for sudden unexpected infant death (SUID). Despite this knowledge, products that deviate from the American Academy of Pediatrics (AAP) safe sleep recommendations continue to be ...
Laura R. Sangaré   +4 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

A nonextensive insight to the stellar initial mass function

open access: yes, 2019
the present paper, we propose that the stellar initial mass distributions as known as IMF are best fitted by $q$-Weibulls that emerge within nonextensive statistical mechanics. As a result, we show that the Salpeter's slope of $\sim$2.35 is replaced when
da Silva, J. R. P.   +3 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Insect insights [PDF]

open access: yesCurrent Biology, 2009
SummaryA new book highlights the lessons from nineteenth-century bug collectors. Nigel Williams reports.
openaire   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Home - About - Disclaimer - Privacy