Results 141 to 150 of about 1,430,196 (268)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Artificial Intelligence Centrality in Psychotic Delusions and Violence Risk in Forensic Psychiatry: Retrospective Observational Study of Judicial Decisions. [PDF]

J Med Internet Res
Hudon A, Pagé C.
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Interleukin 6 as a Treatment Target for Depression: A Proof-of-Concept Randomized Clinical Trial.

JAMA Psychiatry
Foley ÉM, Turner N, Margelyte R, Jones HJ, Kaser M, Lewis G, Jones PB, Khandaker GM.   +7 more
europepmc   +1 more source

Frameworks to Evaluate the Quality of Public Involvement in Health and Social Care Research: A Scoping Review. [PDF]

Health Expect
Hutton R, Moult A, Baker D, Fryer AA, Meakin A, Babatunde O.   +5 more
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Body dysmorphic disorder in Lebanese dermatology patients: prevalence and correlates of depression, anxiety, stress, and trauma in a multitraumatized population. [PDF]

Eur J Psychotraumatol
El Khoury J, Bader E, Hallal M, Salameh P, Abed El Sater R, Maamari M, Habre M, Abadi R, Obeid G, Abou Rahal J, Abi-Habib R.   +10 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Impact of Obesity on the Association Between Salt Intake and Blood Pressure in Adult Men With Hypertension Who Participated in the Remote Lifestyle Intervention

Journal of Obesity
Takuji Adachi, Masashi Kanai, Takahiro Miki, Kotoe Shimizu, Michitaka Kato, Yuta Hagiwara   +5 more
doaj   +1 more source

Dyadic effects of role adaptation on postpartum anxiety and depression: the mediating role of future time insight and parenting competence. [PDF]

BMC Psychiatry
Fu C, Zhang S, Wei Z, Yu X, Zhang B, Gu S, Hu J.   +6 more
europepmc   +1 more source