Results 61 to 70 of about 746,005 (335)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Model Penentuan Ukuran Batch Produksi dan Bufferstock untuk Sistem Produksi Mengalami Penurunan Kinerja dengan Mempertimbangkan Perubahan Order Awal

Jurnal Optimasi Sistem Industri, 2016
This study develops a model that involves information the preliminary order. At first, the manufacturer provides the preliminary order for the coming week (five days) varies from day to day and is received on Friday.
Ivan D Wangsa
doaj   +1 more source

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source

Seeking out non-public information : sell-side analysts and the freedom of information act [PDF]

, 2019
A number of sell-side healthcare analysts gain access to information outside the purview of management through Freedom of Information Act requests to the Food and Drug Administration for records on factory inspections, complaints, and drug and medical ...
Klein, April, Li, Tao, Zhang, Bobo
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

PENGARUH KOMPENSASI DAN LINGKUNGAN KERJA TERHADAP KINERJA KARYAWAN DIVISI QIP PT. GSI CIANJUR

Jurnal Ilmiah Teknik Industri, 2014
The role of human resource management is continously improved to enhance the performance of employees. PT GSI, as one of Indonesian company producing shoe products to meet demand from all around the world, needs employees with high performance.
Suharyanto Suharyanto, Ery Nugraha, Hendra Permana   +2 more
doaj   +3 more sources

Ageing Assessment and Management at Major-Hazard Industries

Chemical Engineering Transactions, 2018
As a consequence of the obligations of the Directive Seveso III, there is a need of methods and tools that support industrial managers and the auditors, respectively, to manage and to verify the ageing status of critical equipment.
Francesca Milazzo Maria, Paolo Bragatto, Giuseppa Ancione, Giuseppe Scionti   +3 more
doaj   +1 more source

Suitable classification of mortars from ancient roman and renaissance frescoes using thermal analysis and chemometrics [PDF]

, 2015
Background Literature on mortars has mainly focused on the identification and characterization of their components in order to assign them to a specific historical period, after accurate classification.
Campanella, Luigi, F., Marinucci, M., Positano, Marini, Federico, Tomassetti, Mauro   +4 more
core   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source