A 3D biomimetic OS model was developed by bioprinting an OS‐cell‐derived dECM‐enriched bioink with OS spheroids incorporated. The model showed upregulation of known OS prognostic markers and increased resistance to doxorubicin, compared to 2D cultures and scaffold‐free spheroids, making this a more clinically relevant platform for drug discovery ...
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Patient self-inflicted lung injury an important phenomenon. [PDF]
Balzani E +3 more
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Monitoring of invasive assisted mechanical ventilation: a good clinical practice document by the Italian Society of Anesthesia, Analgesia, Resuscitation, and Intensive Care (SIAARTI). [PDF]
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Continuous and noninvasive respiratory effort monitoring: a narrative review of emerging techniques. [PDF]
Graßhoff J +4 more
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Safe spontaneous breathing with helmet noninvasive ventilation in acute hypoxemic respiratory failure. [PDF]
Rosà T +4 more
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Physiological comparison of noninvasive ventilation and CPAP on inspiratory efforts after extubation in critically ill patients with morbid obesity: a post-hoc analysis. [PDF]
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Techniques to monitor respiratory drive and inspiratory effort
Current Opinion in Critical Care, 2020Purpose of review There is increased awareness that derangements of respiratory drive and inspiratory effort are frequent and can result in lung and diaphragm injury together with dyspnea and sleep disturbances.
Irene Telias, Savino Spadaro
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Esophageal and transdiaphragmatic pressure swings as indices of inspiratory effort
Respiratory Physiology & Neurobiology, 2021To describe the correlation between the inspiratory esophageal and transdiaphragmatic pressure swings (ΔPes and ΔPdi), easily measured indices of inspiratory effort, with the gold-standard, the transdiaphragmatic pressure time product (PTPPdi/min), and assess the accuracy of swing pressures in predicting very high or low effort.Retrospective analysis ...
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Evolution of Diaphragm Thickness during Mechanical Ventilation. Impact of Inspiratory Effort
American Journal of Respiratory and Critical Care Medicine, 2015Diaphragm atrophy and dysfunction have been reported in humans during mechanical ventilation, but the prevalence, causes, and functional impact of changes in diaphragm thickness during routine mechanical ventilation for critically ill patients are unknown.To describe the evolution of diaphragm thickness over time during mechanical ventilation, its ...
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