Results 41 to 50 of about 15,338 (233)

Helium-Oxygen in the Postextubation Period Decreases Inspiratory Effort

American Journal of Respiratory and Critical Care Medicine, 2001
Abstract After tracheal extubation, upper and total airway resistances may frequently be increased resulting in an increase in inspiratory effort to breathe. We tested whether breathing a helium-oxygen mixture (HeO2) would reduce inspiratory effort in the period after extubation.
Jaber, S, Carlucci, A, Boussarsar, M, Fodil, R, Pigeot, J, MAGGIORE, Salvatore Maurizio, Harf, A, Isabey, D, Brochard, L.   +8 more
openaire   +4 more sources

Orthopnea and inspiratory effort in chronic heart failure patients

Respiratory Medicine, 2003
Orthopnea is a typical feature of patients with chronic heart failure (CHF), the factors contributing to it are not completely understood. We investigated changes in dyspnea and other respiratory variables, induced by altering posture (from sitting to supine) in 11 CHF patients (NYHA classes II-IV) and 10 control subjects.We measured dyspnea (Borg ...
Nava S, Larovere MT, Fanfulla F, Navalesi P, Delmastro M, Mortara A   +5 more
openaire   +5 more sources

Guiding Inspiratory Flow: Development of the In-Check DIAL G16, a Tool for Improving Inhaler Technique

Pulmonary Medicine, 2017
Portable inhalers are divisible into those that deliver medication by patient triggering (pMDIs: a gentle slow inhalation) and those that use the patient’s inspiratory effort as the force for deaggregation and delivery (DPIs: a stronger deeper ...
Mark Jeremy Sanders
doaj   +1 more source

Identifying asynchronies: Reverse trigger

Journal of Mechanical Ventilation, 2022
A variety of asynchronies between the patient’s respiratory efforts and the programed ventilatory settings have been categorized. Reverse trigger is described as an inspiratory effort occurring after a ventilator-initiated breath and may represent a ...
Víctor Perez, Jamille Pasco
doaj   +1 more source

Spontaneous Inspiratory Effort During Lung-Protective Ventilation [PDF]

Respiratory Care, 2019
The reduction of tidal volume during controlled mechanical ventilation of patients with ARDS has proven to be one of the few specific interventions in critical care that can save lives.[1][1] Indeed, there is some evidence that lung-protective ventilation strategies, including tidal volume ...
openaire   +2 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Respiratory Variations of Central Venous Pressure as Indices of Pleural Pressure Swings: A Narrative Review

Diagnostics, 2023
The measurement of pleural (or intrathoracic) pressure is a key element for a proper setting of mechanical ventilator assistance as both under- and over-assistance may cause detrimental effects on both the lungs and the diaphragm.
Michele Umbrello, Sergio Cereghini, Stefano Muttini   +2 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Risk Factors for Pulmonary Air Leak and Clinical Prognosis in Patients With COVID-19 Related Acute Respiratory Failure: A Retrospective Matched Control Study

Frontiers in Medicine, 2022
BackgroundThe role of excessive inspiratory effort in promoting alveolar and pleural rupture resulting in air leak (AL) in patients with SARS-CoV-2 induced acute respiratory failure (ARF) while on spontaneous breathing is undetermined.MethodsAmong all ...
Roberto Tonelli, Roberto Tonelli, Giulia Bruzzi, Linda Manicardi, Luca Tabbì, Riccardo Fantini, Ivana Castaniere, Ivana Castaniere, Dario Andrisani, Dario Andrisani, Filippo Gozzi, Filippo Gozzi, Maria Rosaria Pellegrino, Fabiana Trentacosti, Lorenzo Dall’Ara, Stefano Busani, Erica Franceschini, Serena Baroncini, Gianrocco Manco, Marianna Meschiari, Cristina Mussini, Massimo Girardis, Bianca Beghè, Alessandro Marchioni, Enrico Clini   +24 more
doaj   +1 more source