Results 111 to 120 of about 3,048,905 (395)

Deep cell phenotyping and spatial analysis of multiplexed imaging with TRACERx-PHLEX

open access: yesNature Communications
The growing scale and dimensionality of multiplexed imaging require reproducible and comprehensive yet user-friendly computational pipelines. TRACERx-PHLEX performs deep learning-based cell segmentation (deep-imcyto), automated cell-type annotation ...
Alastair Magness   +18 more
doaj   +1 more source

A molecular portrait of microsatellite instability across multiple cancers

open access: yesNature Communications, 2016
Microsatellite instability (MSI) refers to the hypermutability of short repetitive sequences in the genome caused by impaired DNA mismatch repair. Although MSI has been studied for decades, large amounts of sequencing data now available allows us to ...
I. Cortés-Ciriano   +4 more
semanticscholar   +1 more source

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

open access: yesMolecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton   +17 more
wiley   +1 more source

Integrated simulation and monitoring to analyze failure mechanism of the anti-dip layered slope with soft and hard rock interbedding

open access: yesInternational Journal of Mining Science and Technology, 2023
The significant difference between the mechanical properties of soft rock and hard rock results in the complexity of the failure mode of the anti-dip layered slope with soft and hard rock interbedding.
Jinduo Li   +7 more
doaj  

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

open access: yesMolecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop   +10 more
wiley   +1 more source

Limit-Cycle Properties of a Rijke Tube [PDF]

open access: yes, 2003
Thermoacoustic instability appears when unsteady heat release is favourably coupled with acoustic pressure perturbations. The important technical applications involving thermoacoustics are combustion instability in rocket motors and low-pollutant lean ...
Culick, F. E. C., Matveev, K. I.
core  

Chronic Ankle Instability Leads to Lower Extremity Kinematic Changes During Landing Tasks: A Systematic Review

open access: yesInternational Journal of Exercise Science, 2019
Ankle and knee injuries are two of the most common injuries. It has been shown that ankle sprains can lead to chronic ankle instability thereby affecting the function of the ankle.
Aaron Theisen, James Day
semanticscholar   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

open access: yesMolecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski   +19 more
wiley   +1 more source

Experimental Investigation of Flow Domain Division in Beds Packed with Different Sized Particles

open access: yesEnergies, 2017
Seepage in a medium packed with particles of variable granular size can be seen in many fields of engineering applications. Due to the relative complex spatial aspect of pore geometry, there are notable differences in the critical parameters of flow ...
Xin Yang   +3 more
doaj   +1 more source

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