Results 81 to 90 of about 2,390,832 (281)

Deep cell phenotyping and spatial analysis of multiplexed imaging with TRACERx-PHLEX

open access: yesNature Communications
The growing scale and dimensionality of multiplexed imaging require reproducible and comprehensive yet user-friendly computational pipelines. TRACERx-PHLEX performs deep learning-based cell segmentation (deep-imcyto), automated cell-type annotation ...
Alastair Magness   +18 more
doaj   +1 more source

Mechanisms of the Vertical Secular Heating of a Stellar Disk

open access: yes, 2003
We investigate the nonlinear growth stages of bending instability in stellar disks with exponential radial density profiles.We found that the unstable modes are global (the wavelengths are larger than the disk scale lengths) and that the instability ...
A. Jenkins   +39 more
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Numerical Simulation on Damage and Failure Mechanism of Rock under Combined Multiple Strain Rates

open access: yesShock and Vibration, 2018
During underground hard-rock mining, the drilling and blasting method currently remains the most economical excavation method, and the rock may experience a multistrain-rate spectrum under quasi-static, dynamic, and rheological loading conditions and ...
Wancheng Zhu   +4 more
doaj   +1 more source

A simple toy model of the advective-acoustic instability I. Perturbative approach

open access: yes, 2008
Some general properties of the advective-acoustic instability are described and understood using a toy model which is simple enough to allow for analytical estimates of the eigenfrequencies.
Blondin   +18 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Author Correction: ID3 regulates the MDC1-mediated DNA damage response in order to maintain genome stability

open access: yesNature Communications, 2018
This Article contains errors in Fig. 3, Fig. 4 and Fig. 7, for which we apologize. In Fig. 3, panel ‘b’, the 0.5 hour time point after Ku55933 treatment images were inadvertently replaced with duplicates of the 3 hour time point after Ku55933 treatment ...
Jung-Hee Lee   +11 more
doaj   +1 more source

Driven Intrinsic Localized Modes in a Coupled Pendulum Array

open access: yes, 2007
Intrinsic localized modes (ILMs), also called discrete breathers, are directly generated via modulational instability in an array of coupled pendulums. These ILMs can be stabilized over a range of driver frequencies and amplitudes. They are characterized
A J Sievers   +4 more
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Conditional Random Field Approach Combining FFT Filtering and Co-Kriging for Reliability Assessment of Slopes

open access: yesApplied Sciences
Conventional unconditional random field (URF) models were shown to neglect in-situ monitoring data and thus misrepresent real slope stability. To address this, a conditional random field (CRF) generator was proposed, in which Fast Fourier Transform (FFT)
Xin Dong   +7 more
doaj   +1 more source

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