Results 81 to 90 of about 3,048,905 (395)

Nonlinear mirror instability

open access: yes, 2014
Slow dynamical changes in magnetic-field strength and invariance of the particles' magnetic moments generate ubiquitous pressure anisotropies in weakly collisional, magnetized astrophysical plasmas.
Cowley, S. C.   +2 more
core   +1 more source

Instability driven by boundary inflow across shear: a way to circumvent Rayleigh's stability criterion in accretion disks? [PDF]

open access: yes, 2015
We investigate the 2D instability recently discussed by Gallet et al. (2010) and Ilin \& Morgulis (2013) which arises when a radial crossflow is imposed on a centrifugally-stable swirling flow. By finding a simpler rectilinear example of the instability -
Kerswell, R. R.
core   +2 more sources

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi   +26 more
wiley   +1 more source

Research on the Dynamic Response Patterns of Layered Slopes Considering Non-Homogeneity Under Blast-Induced Vibration Effects

open access: yesApplied Sciences
To investigate the dynamic wave propagation characteristics and dynamic response of heterogeneous layered slopes under a blasting vibration, a modeling method considering the slope’s layered dip angle and heterogeneity was proposed. Different dip jointed
Yong Zhao   +5 more
doaj   +1 more source

ID3 regulates the MDC1-mediated DNA damage response in order to maintain genome stability

open access: yesNature Communications, 2017
MDC1 is a key component of the DNA damage response and interacts with several factors such as γ-H2AX. Here the authors show that MDC1 interacts with ID3, facilitating MDC1 recruitment to sites of damage and repair of breaks.
Jung-Hee Lee   +11 more
doaj   +1 more source

Numerical Shear Tests on the Scale Effect of Rock Joints under CNL and CND Conditions

open access: yesAdvances in Civil Engineering, 2020
The scale effect of rock joint shear behavior is an important subject in the field of rock mechanics. There is yet a lack of consensus regarding whether the shear strength of rock joints increases, decreases, or remains unchanged as the joint size ...
Xige Liu, Wancheng Zhu, Lankun Li
doaj   +1 more source

Instabilities in the dissolution of a porous matrix [PDF]

open access: yes, 2011
A reactive fluid dissolving the surrounding rock matrix can trigger an instability in the dissolution front, leading to spontaneous formation of pronounced channels or wormholes.
A. J. C. Ladd   +18 more
core   +2 more sources

The Dynamics of Instability

open access: yesTheoretical Economics
We study a model in which two players with opposing interests try to alter a status quo through instability‐generating actions. We show that instability can be used to secure longer‐term durable changes, even if it is costly to generate and does not generate short‐term gains.
Barilla, César, Gonçalves, Duarte
openaire   +3 more sources

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

Analysis of Surrounding Rock Stability Based on Refined Geological and Mechanical Parameter Modeling—A Case Study

open access: yesApplied Sciences
Metallic ore deposits are generally formed through magmatic intrusions, followed by metamorphism. The geological structures in such regions are often complex, with mechanical parameters exhibiting significant variability.
Guangzhi Chai   +5 more
doaj   +1 more source

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