Results 81 to 90 of about 3,165,406 (373)

MicroRNA-145 Impairs Classical Non-Homologous End-Joining in Response to Ionizing Radiation-Induced DNA Double-Strand Breaks via Targeting DNA-PKcs

Cells, 2022
DNA double-strand breaks (DSBs) are one of the most lethal types of DNA damage due to the fact that unrepaired or mis-repaired DSBs lead to genomic instability or chromosomal aberrations, thereby causing cell death or tumorigenesis.
Muddenahalli Srinivasa Sudhanva, Gurusamy Hariharasudhan, Semo Jun, Gwanwoo Seo, Radhakrishnan Kamalakannan, Hyun Hee Kim, Jung-Hee Lee   +6 more
doaj   +1 more source

Gravitational Radiation Instability in Hot Young Neutron Stars [PDF]

, 1998
We show that gravitational radiation drives an instability in hot young rapidly rotating neutron stars. This instability occurs primarily in the l=2 r-mode and will carry away most of the angular momentum of a rapidly rotating star by gravitational ...
Benjamin J. Owen, C. Cutler, J. Ipser, J. Papaloizou, J. Provost, K. S. Thorne, L. Lindblom, Lee Lindblom, O. Blaes, R. F. Sawyer, S. Bonazzola, S. L. Shapiro, Sharon M. Morsink   +12 more
core   +2 more sources

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

Molecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton, Russell W. Madison, Candice Francheska B. Tambaoan, Funda Meric‐Bernstam, Christopher J. Sweeney, Razelle Kurzrock, Howard A. Burris III, David R. Spigel, Hanna Tukachinsky, Jason Hughes, Julia Malato, Bongin Yoo, Tania Szado, Cheryl Schwab, Lincoln W. Pasquina, Amaya Gasco, Katja Schulze, Claire F. Friedman   +17 more
wiley   +1 more source

Curvature scalar instability in f(R) gravity [PDF]

, 2006
An instability in the presence of matter in theories of gravity which include a 1/R correction in the gravitational action has been found by Dolgov and Kawasaki. In the present paper this instability is discussed for f(R) gravity in general.
Allemandi, Allemandi, Allemandi, Allemandi, Amendola, Amendola, Barrow, Brookfield, Buchbinder, Buchdahl, Capozziello, Capozziello, Capozziello, Capozziello, Carroll, Cembranos, Clifton, Dolgov, Easson, Erickcek, Faraoni, Faraoni, Ferraris, Ferraris, Flanagan, Hehl, Kunstatter, Maeda, Magnano, Navarro, Nojiri, Nojiri, Nojiri, Nojiri, Nojiri, Olmo, Papapetrou, Sotiriou, Sotiriou, Sotiriou, Sotiriou, Sotiriou, Sotiriou, Soussa, Spergel, Starobinsky, Stelle, Teyssandier, Thomas P. Sotiriou, Vollick, Wands, Whitt   +51 more
core   +4 more sources

Pulsational Pair-instability Supernovae [PDF]

, 2016
The final evolution of stars in the mass range 70–140 M ⊙ is explored. Depending upon their mass loss history and rotation rates, these stars will end their lives as pulsational pair-instability supernovae (PPISN) producing a great variety of ...
S. Woosley
semanticscholar   +1 more source

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

Molecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop, Edgar Cardenas De La Hoz, Hanne Verswyvel, Joey De Backer, Ho Wa Lau, Angela Privat‐Maldonado, Wim Vanden Berghe, Steve Vanlanduit, Evelien Smits, Annemie Bogaerts, Abraham Lin   +10 more
wiley   +1 more source

Research on the Dynamic Response Patterns of Layered Slopes Considering Non-Homogeneity Under Blast-Induced Vibration Effects

Applied Sciences
To investigate the dynamic wave propagation characteristics and dynamic response of heterogeneous layered slopes under a blasting vibration, a modeling method considering the slope’s layered dip angle and heterogeneity was proposed. Different dip jointed
Yong Zhao, Yanjie Liu, Shihui Jiao, Tianhong Yang, Wenxue Deng, Shuhong Wang   +5 more
doaj   +1 more source

ID3 regulates the MDC1-mediated DNA damage response in order to maintain genome stability

Nature Communications, 2017
MDC1 is a key component of the DNA damage response and interacts with several factors such as γ-H2AX. Here the authors show that MDC1 interacts with ID3, facilitating MDC1 recruitment to sites of damage and repair of breaks.
Jung-Hee Lee, Seon-Joo Park, Gurusamy Hariharasudhan, Min-Ji Kim, Sung Mi Jung, Seo-Yeon Jeong, In-Youb Chang, Cheolhee Kim, Eunae Kim, Jihyeon Yu, Sangsu Bae, Ho Jin You   +11 more
doaj   +1 more source

A prediction model for surface deformation caused by underground mining based on spatio-temporal associations

Geomatics, Natural Hazards & Risk, 2022
Accurate predictions of the surface deformation caused by underground mining are crucial for the safe development of underground resources. Although surface deformation has been predicted by artificial intelligence (AI) methods, most AI models are ...
Min Ren, Guanwen Cheng, Wancheng Zhu, Wen Nie, Kai Guan, Tianhong Yang   +5 more
doaj   +1 more source

Thermo-Resistive Instability of Hot Planetary Atmospheres

, 2012
The atmospheres of hot Jupiters and other strongly-forced exoplanets are susceptible to a thermal instability in the presence of ohmic dissipation, weak magnetic drag and strong winds.
Baraffe, Batygin, Batygin, Burrows, Burrows, Charbonneau, Cowan, Fortney, Fortney, Fortney, Goody, Hubeny, Knutson, Laughlin, Madhusudhan, Menou, Perna, Perna, Perna, Rauscher, Seager, Showman, Winn, Wu   +23 more
core   +1 more source