Results 31 to 40 of about 39,850 (259)
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
IEEE Access, 2019 The rotation semi-strapdown inertial navigation system (RSSINS) provides a new solution for the high-precision measurement of high-spinning projectile flight parameters.
Jiayu Zhang +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Effect of Installation Errors of Helical Gear on Bearing Capacity
, 2023 Broken tooth roots due to mounting errors in helical gears at high speeds and heavy loads are a common problem in steel mills. Based on the contact characteristics of helical gears, this paper uses the finite element method to simulate the bending stress at the root of the pinion gear and the contact stress at the tooth surface under two cases of ...
Luan, Heng, Shu, Xiantao, Wang, Jiabing
openaire +1 more source
Applied Sciences, 2020 The mirror unit installation error of the solar parabolic dish concentrator can adversely affect its optical performance causing optical intercept losses and hot spots on the absorber surface, which in turn affect safety.
Jian Yan, Youduo Peng, Duzhong Nie
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Vibration Characterization of Ship Propulsion System Including Stern-Bearing Installation Errors
Journal of Marine Science and EngineeringDuring the operation and service of a ship, its power system will affect the stability, reliability, and safety of the ship’s power system and the ship’s vitality if there are typical problems, such as unstable operation and vibration of the shaft system.
Jianhua Zhou +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source