Results 51 to 60 of about 39,954 (258)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Calibration and compensation methods of installation error of electronic compass
Journal of Measurement Science and Instrumentation, 2013 Installation error angle is one of the factors that affect the accuracy of electronic compass used for geomagnetic navigation.To solve this problem,the calibration and compensation methods for installation error angle are studied.By analyzing the ...
FAN Cheng-ye +6 more
doaj
Research on Transmission Error of Hypoid Gear based on Real Tooth Surface
Jixie chuandong, 2022 Aiming at the inconsistency evaluation standards caused by using the gear designed by theory for simulation and using the gear produced by actual production for roll inspection certificate test，by using the NURBS surface fitting method，the real tooth ...
Yimin Mo +5 more
doaj
Research on Eccentric Error Compensation of Aviation Gear Grinding Installation
Hangkong gongcheng jinzhan, 2018 There is eccentric error between the geometric center of the gear blank and the axis of the rotary table during the gear grinding process. The machining precision of grinding tooth accuracy is reduced.
Wang Peng +3 more
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Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
The bearing parallel misalignment running model–based machine tool spindle thermal error analysis
Advances in Mechanical Engineering, 2018 As a key component of the machine tool spindle, bearing has critical influences on the spindle thermal error. In particular, the installation errors of bearing have considerable effects upon the spindle thermal error by altering the bearings’ internal ...
Yanfang Dong, Zude Zhou, Lihai Chen
doaj +1 more source
A New Method of Angle Measurement Error Analysis of Rotary Encoders
Applied Sciences, 2019 In this article, a method of error source analysis and detection to improve the angle measurement accuracy of rotary encoders in precision measuring instruments is proposed.
Hua-Kun Jia +3 more
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FEBS Open Bio, EarlyView.The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong +3 more
wiley +1 more source