Results 41 to 50 of about 411,092 (298)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

A Method for the Installation Measurement and Alignment of a Mirror Unit in the Solar Dish Concentrator

Applied Sciences, 2020
The mirror unit installation error of the solar parabolic dish concentrator can adversely affect its optical performance causing optical intercept losses and hot spots on the absorber surface, which in turn affect safety.
Jian Yan, Youduo Peng, Duzhong Nie
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Vibration Characterization of Ship Propulsion System Including Stern-Bearing Installation Errors

Journal of Marine Science and Engineering
During the operation and service of a ship, its power system will affect the stability, reliability, and safety of the ship’s power system and the ship’s vitality if there are typical problems, such as unstable operation and vibration of the shaft system.
Jianhua Zhou, Shidong Fan, Hanhua Zhu, Yulei Zhu, Hailong Weng, Junlang Yuan, Taiwei Yang   +6 more
doaj   +1 more source

PERANCANGAN APLIKASI ELECTRONIC MEDICAL RECORD (EMR) PADA INSTALASI RAWAT INAP BERBASIS WEB [PDF]

, 2011
Pelayanan medik dewasa ini membutuhkan sistem yang lebih efektif dan efisien, baik dalam penggunaan waktu, tenaga maupun sarana. Dalam pengelolaan rekam medik, kenyataan masih umumnya penggunaan rekam medik manual yang dinilai tak lagi andal menangani ...
Handoyo, Eko, Muttaqin, Moh, Sofwan, Aghus   +2 more
core  

Effect of Installation Errors of Helical Gear on Bearing Capacity

, 2023
Broken tooth roots due to mounting errors in helical gears at high speeds and heavy loads are a common problem in steel mills. Based on the contact characteristics of helical gears, this paper uses the finite element method to simulate the bending stress at the root of the pinion gear and the contact stress at the tooth surface under two cases of ...
Luan, Heng, Shu, Xiantao, Wang, Jiabing
openaire   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Research on Calibration Method of Triaxial Accelerometer in Speed Calculation of Maglev Train

机车电传动, 2019
For the error of the accelerometer leads to inaccurate calculation of the vehicle speed in the MEMS accelerometer-based maglev train speed calculation scheme, a new method of error calibration was proposed.
Chuanming SUN, Shaolong XU, Weiwei GAN, Zhengfang ZHANG, Jie JIANG   +4 more
doaj