Results 81 to 90 of about 411,092 (298)

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Calculation and Analysis of Meshing Stiffness of Helical Gear Considering Installation Error

Jixie chuandong, 2017
The analysis calculation of meshing stiffness of helical gear is the basis for the study of gear dynamics. According to the gear meshing principle and coordinate transformation theory the finite element model of helical gear meshing with the installation
Liu Baoshan, Du Qungui, Wen Qi
doaj  

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Planetary explorer liquid propulsion study [PDF]

An analytical evaluation of several candidate monopropellant hydrazine propulsion system approaches is conducted in order to define the most suitable configuration for the combined velocity and attitude control system for the Planetary Explorer ...
Bolz, C. W., Eggers, R. F., Mckevitt, F. X.   +2 more
core   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

Contact Analysis of Cylindrical Helical Gear Considering the Hob Installation Error

Jixie chuandong, 2016
The high precision gear processing must consider the influence of machining error on the meshing quality,based on the basic principle of the contact analysis of helical gear,the simulation of involute helical gear is realized by using the Matlab software,
Zhang Rui, Wu Zhifei, Wang Tie, Yan Tianxiao, Wu Pingan, Qiao Jinwei   +5 more
doaj  

LHC Installation Scenarios and Dynamic Aperture [PDF]

, 2000
The nominal installation strategy of the LHC assumes that each of the 8 arcs of the ring will be equipped with dipoles coming from the same production line.
Fartoukh, Stéphane David
core  

Accelerator Design for the CHESS-U Upgrade

, 2019
During the summer and fall of 2018 the Cornell High Energy Synchrotron Source (CHESS) is undergoing an upgrade to increase high-energy flux for x-ray users.
Barley, J., Barrett, S., Billing, M., Codner, G., Li, Y., Liu, X., Lyndaker, A., Rice, D., Rider, N., Rubin, D. L., Shanks, J., Temnykh, A., Wang, S. T.   +12 more
core   +1 more source

Sex Differences in Medication Discontinuation in Axial Spondyloarthritis

Arthritis Care &Research, EarlyView.
Objective We examined sex differences in medication discontinuation among patients with axial spondyloarthritis (axSpA) initiating tumor necrosis factor inhibitors (TNFi), interleukin‐17 inhibitors (IL‐17i), or JAK inhibitors (JAKi). Methods Using data from the Rheumatology Informatics System for Effectiveness (RISE) Registry (2003–2025), we assessed ...
Rachael Stovall, Cinthia Blat, Eric Roberts, Jean W. Liew, Katherine Wysham, Namrata Singh, Janna Friedly, Lianne S. Gensler, Gabriela Schmajuk, Jinoos Yazdany   +9 more
wiley   +1 more source

Analysis of Bearing Contact Characteristics of Face Gear Drives with Coupling Installation Errors

Jixie chuandong
A modeling method of finite element model for precise assembly of face gear transmission with installation error coupling was studied, and the bearing contact characteristics of face gear transmission were analyzed.
Weng Dengyan, Shen Yunbo, Xu Weijun
doaj