Results 41 to 50 of about 16,163 (259)

The Animal in Man ─ An Image Pattern in Frank Norris’ Mcteague

open access: yesJournal of Language and Literature, 2023
Every man possesses an animal instinct that lingers beneath the surface, waiting for an appropriate time to manifest. In Frank Norris’ McTeague, some characters degenerate to the level of the animal, displaying brutality and striving like predators for ...
Godwin Yao Gaaku   +2 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Rebecca Horn, corps sous tension

open access: yesCahiers d’Études Germaniques, 2020
This article highlights the continuity between Rebecca Horn’s performances from the 1970’s and the kinetic sculptures she has been creating since the 1990’s. In her later work, the machines have replaced the human body, yet in her performances the artist,
Léa Barbisan
doaj   +1 more source

Continuous instinct control for powered knee-ankle prostheses [PDF]

open access: yesMATEC Web of Conferences, 2020
In order to improve the life quality of lower extremity amputees, many researchers have studied the powered knee-ankle prosthesis. Various parameters must necessarily be adjusted for the finite state machine impedance model method.
Shen Kaixin   +3 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

open access: yesFEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard   +12 more
wiley   +1 more source

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

open access: yesHepatology, EarlyView., 2022
Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández   +18 more
wiley   +1 more source

A Model for Basic Emotions Using Observations of Behavior in Drosophila

open access: yesFrontiers in Psychology, 2019
Emotion plays a crucial role, both in general human experience and in psychiatric illnesses. Despite the importance of emotion, the relative lack of objective methodologies to scientifically studying emotional phenomena limits our current understanding ...
Simeng Gu   +7 more
doaj   +1 more source

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan   +5 more
wiley   +1 more source

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