Results 51 to 60 of about 26,113,156 (202)

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

ECONOMIC GROWTH UNDER THE INFLUENCE OF TECHNICAL AND TECHNOLOGICAL CHANGES OF INDUSTRY 5.0

open access: yesBaltic Journal of Economic Studies
The purpose of the scientific research is to graphically present and scientifically analyse economic growth under the influence of digital production factors as a result of technical progress, technological improvement and the use of Industry 5.0 tools.
Kateryna Kraus   +2 more
doaj   +1 more source

Small and Medium Enterprises in the Russian Transaction Sector

open access: yesМодернизация, инновация, развитие, 2019
Purpose: to study the significance of small and medium enterprises for the functioning of the modern Russian transaction sector.Methods: the paper used General scientific research methods: analysis and synthesis, abstraction, generalization.
I. M. Gurova
doaj   +1 more source

Political Entrepreneurship and Institutional Change: an Evolutionary Approach [PDF]

open access: yes
The paper is a contribution to the theory of institutional change. Using a process-based, evolutionary framework, a comparative analysis of economic and political entrepreneurship is provided and implications are derived for the role of political ...
Hederer, Christian
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

An institutional approach to service-provision partnerships in South Asia

open access: yes, 2005
Radical approaches to introduce public-private partnerships (PPPs) for infrastructure provision in South Asia have been largely unsuccessful. Yet the region is home to a thriving informal private sector and several regional NGOs have become engaged in ...
Tayler, Kevin
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

PROPERTY AND SOCIAL-ECONOMIC JUSTICE: INSTITUTTIONAL APPROACH

open access: yesRussian Journal of Economics and Law, 2007
In the socially significant rate the social-economic justice is the criteria of righteous and purposeful property relations and their transformation at the certain historical stage.
I. A. Kabasheva
doaj  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

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