Results 101 to 110 of about 2,196,057 (314)

2024-04-12 Institutional Animal Care and Use Committee Meeting Minutes [PDF]

The meeting minutes of the Institutional Animal Care and Use Committee for April 12 ...
Morehead State University. Faculty Senate., Institutional Animal Care and Use Committee.   +1 more
core  

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Construct Validity of the Spanish Version of the CHAMPS Questionnaire for institutionalized patients over 65 years old

Motriz: Revista de Educacao Fisica
This study investigates the construct validity of the Spanish version of the CHAMPS questionnaire with institutionalized older adults between the ages of 74 and 90.
José M. Cancela, Carlos Ayán, Miguel A. Sánchez-Lastra, Ángel Casal   +3 more
doaj   +1 more source

Quality of life of the elderly residents of nursing homes and patients of the Psychogeriatric Day Ward

Journal of Medical Science, 2017
Introduction. Due to the prolonged average life span and constantly increasing number of the elderly, research of this population’s quality of life (QoL) is being conducted to assess the spheres requiring improvement. Aim. To assess and compare the life
Magdalena Pawlaczyk, Teresa Gąsior, Michał Michalak, Andrzej Jóźwiak, Ewa Zasadzka, Monika Matecka, Mariola Pawlaczyk   +6 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Managing Institutional Diversity in Integrated Care: A Systematic Literature Review of Institutional Logics and Management Strategies

Introduction: This review examines the institutional diversity in integrated care due to various institutional logics and explores the essential management strategies for navigating this diversity effectively.Methods: This systematic literature review ...
Roth, Marco
core   +1 more source

Digital Health & Care Innovation Centre Phase 2 – Year 3 Annual Report (August 2021 to July 2022) [PDF]

, 2022
This Year 3 annual report sets out the significant impact made by DHI over the past 12 months with continued success to report evident, including 5 projects transferred to other organisations as ready to scale.
Digital Health & Care Institute (DHI)
core  

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source