Results 121 to 130 of about 3,551,588 (309)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Determinants of Malnutrition among Elderly Women Living in Institutional Care. [PDF]

J Midlife Health, 2023
Moses JS, John S, Monica SJ, Priyadarshini S.   +3 more
europepmc   +1 more source

Submission in response to the Australian Government’s Consultation Paper on the Establishment of the Royal Commission into Institutional Responses to Child Sexual Abuse [PDF]

A submission in response to the Australian Government\u27s Consultation Paper on the Establishment of the Royal Commission into Institutional Responses to Child Sexual Abuse.
Cate O', Cathy Humphreys, Debra Rosser, Gavan McCarthy, Mike Jones, Shurlee Swain   +5 more
core  

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Perceptions of Care in Residential Facilities According to Functional Dependency: A Phenomenological Approach Centred on Older Adults’ Dignity

Societies
Population ageing and the increase in life expectancy have heightened the demand for long-term care in residential facilities. In Spain, it is projected that by 2054 the functional dependency rate among those aged 65 and over will exceed 53.0%, posing ...
Sara Fernández-Ming, María Carmen Martín-Cano, Marta García-Domingo, Adrián Jesús Ricoy-Cano   +3 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Market distortions in the Dutch mixed long-term care market: an exploratory analysis

Health Economics, Policy and Law
Mixed markets can enhance welfare compared to full public or private provision. However, this welfare gain depends on the extent to which market distortions exist. Recent literature demonstrates distortions in mixed long-term care markets worldwide.
Yvonne Krabbe-Alkemade, Peter Makai, Marcel Canoy, Ron Kemp, France Portrait   +4 more
doaj   +1 more source

Multi-institutional Care in Clinical Stage II and III Esophageal Cancer. [PDF]

Ann Thorac Surg, 2023
Rhodin KE, Raman V, Jensen CW, Kang L, Nussbaum DP, Tong BC, Blazer DG, D'Amico TA.   +7 more
europepmc   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

The Role of Contextual Factors in Shaping Urban Older Adults' Intention of Institutional Care in China: A Mixed-Methods Study. [PDF]

Int J Environ Res Public Health, 2023
Li Y, Zhang J, Luo H, Pei X, Wu T, Jing J.   +5 more
europepmc   +1 more source