Results 51 to 60 of about 1,904,166 (240)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Pressões da globalização e a resposta criadora
Cadernos EBAPE.BREste artigo aborda a globalização como um complexo processo de institucionalização e examina o potencial da teoria institucional na elucidação das características do fenômeno, em especial, na forma específica como se manifesta nas regiões periféricas ...
Luiz Alberto da Costa Mariz
doaj +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Leading the church through institutional change
Scandinavian Journal for Leadership & TheologyWhile institutional changes in the religious landscape of Norwegian society have received much scholarly interest in recent decades, less attention has been paid to the agency provided by actors within the Church of Norway.
Helge Nylenna
doaj +1 more source
Entrepreneurs-politiciens : défi ou dérive d’un nouveau genre d’hommes d’affaires en Haïti ?
Études Caribéennes, 2016 In 2015, several Haitian entrepreneurs invested the political arena and wanted to be elected at different levels (mayors, members of Parliament, and president).
Bénédique Paul
doaj +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
The effect of political leaders on economic growth through institutional change
Romanian Economic Journal, 2015 The article summarizes the influence of political leaders on institutions which, according to institutional economics, directly influences economic growth.
Dóra Zolcsák
doaj
Journal of Agricultural and Resource Economics, 1998 This article explores and develops three ideas: (a) that the aridity of western North America and its attendant characteristics have fundamentally shaped the work of western agricultural economists and encouraged some distinctive western contributions to
Bruce A. Weber
doaj +1 more source
Biallelic Inactivation of NSD1 Associated With Carcinogenesis in Sotos Syndrome
Pediatric Blood &Cancer, EarlyView.
Nicholas A. Borja +8 more
wiley +1 more source