Results 51 to 60 of about 17,325,720 (353)

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

open access: yesMolecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim   +8 more
wiley   +1 more source

Crossing the Next Meridian: The Economics of Rural-Urban Interdependence, Institutions, and Income Distribution in the American West

open access: yesJournal of Agricultural and Resource Economics, 1998
This article explores and develops three ideas: (a) that the aridity of western North America and its attendant characteristics have fundamentally shaped the work of western agricultural economists and encouraged some distinctive western contributions to
Bruce A. Weber
doaj   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

On inevitability of political clientelism in contemporary Serbia [PDF]

open access: yesSociologija, 2016
This paper deals with the problem of political clientelism in Serbia broadly defined as the selective distribution of benefits (money, jobs, information, a variety of privileges) to individuals or clearly defined groups in exchange for political
Cvejić Slobodan
doaj   +1 more source

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

open access: yesMolecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

Nudging Evolution?

open access: yesEcology and Society, 2013
This Special Feature, "Nudging Evolution? Critical Exploration of the Potential and Limitations of the Concept of Institutional Fit for the Study and Adaptive Management of Social-Ecological Systems," aims to contribute toward the development of social ...
Katharine N. Farrell, Andreas Thiel
doaj   +1 more source

The Merging of the Higher Educational Institutions: Institutional and Organizational Change [PDF]

open access: yesЖурнал институциональных исследований, 2017
Higher education reforms in Russia had been initiated in response to the challenge of time, such as new technologies development, optimization of government expenditures, commercialization of higher education and its “mass” character.
Vyacheslav V. Volchik   +2 more
doaj   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

open access: yesMolecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen   +12 more
wiley   +1 more source

Locust Control in Transition: The Loss and Reinvention of Collective Action in Post-Soviet Kazakhstan

open access: yesEcology and Society, 2007
The inability to organize collective action for pest control can lead to severe problems. This paper focuses on the locust management system in Kazakhstan since the formation of the Soviet State.
Kazbek Toleubayev   +2 more
doaj   +1 more source

Dacha in Post-Soviet Russia: Institutional Analysis [PDF]

open access: yesЖурнал институциональных исследований, 2017
This paper tries to analyze the phenomenon of «dacha» according to D. North's approach to institutions. The authors explore how dacha has become mass phenomenon in the late USSR, and how social and economic role of dacha increased in the Post-Soviet ...
Rozmainsky Ivan V.   +3 more
doaj   +1 more source

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