Results 71 to 80 of about 2,324,008 (310)

THE ROLE OF PRACTICES IN INSTITUTIONAL CHANGE THE EVOLUTION OF DOCTORAL PROGRAMS IN FRANCE 1990 – 2008 [PDF]

open access: yes
Whether based on the figure of institutional entrepreneur or the dynamic of social movements, models of institutional change have yet to solve the paradox of embedded agency.
Charles Dhanaraj   +2 more
core  

The communicative constitution of institutional change in expression games

open access: yes, 2020
Neo-institutional theory has recently advanced our understanding of the early phase of institutional change but presupposes contexts in which verbally and nonverbally expressing the intended institutional change within a group is already possible.
Schumacher, Thomas   +3 more
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Farvel til normalarbeidsdagen? – En studie av endring i Irland, Norge og Sverige

open access: yesTidsskrift for Samfunnsforskning, 2012
I tiden etter 1980 har ideer om fleksibilitet og deregulering preget debatter om regulering av arbeidstid. I denne artikkelen undersøkes det hvordan den regulerte normalarbeidsdagen har utviklet seg i løpet av de siste 30 år.
Heidi Nicolaisen
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Unpacking the "institutional portfolio" theoretical elements for an analysis of institutional change through objectification of resources and habitus [PDF]

open access: yes
The "social kill" (Fligstein, 1997 and 2001) attributed to social entrepreneurs is ont sufficiently explicit as regards their dispositions for engaging in actions of change. After placing the status of change in the context of institutionalist literature,
Viale, Thierry
core  

Institutional investor influence on global climate change disclosure practices

open access: yes, 2012
Using a stakeholder engagement perspective, we investigate the collective influence of institutional investors on a comprehensive set of climate change disclosures for a global sample of large companies.
Muftah M Najah   +3 more
core   +1 more source

Reimagining a path from institutional willingness to readiness: ecosystem variables that promote or impede sustainable transformation in higher education

open access: yesFrontiers in Education
Many colleges and universities purport agendas involving strategies centered on the readiness to diversify the faculty, staff, and student bodies, modernize curricula, and promote innovation in research and discovery, among other advancements.
Joseph A. Whittaker   +1 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

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