Results 81 to 90 of about 23,831,433 (300)

Preference formation and institutional change

Brazilian Political Science Review, 2009
This essay critically analyses how historical institutionalists and rational choice scholars study institutional stability and change. Special attention is paid to the thorny issued of how political actors’ preferences are formed, with historical ...
Sérgio Praça
doaj  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Contemporary Research on Agency in Education: A Systematization of Key Concepts and Developments

Вопросы образования
The task of developing individual "agency" (autonomy, proactivity, initiative, etc.), in education is widely discussed in scientific and practical circles.
Pavel S. Sorokin, Timofey D. Redko
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Planning for waterway renewal: balancing institutional reproduction and institutional change [PDF]

, 2018
Modern waterway networks are ageing and need to be renewed, yet the institutional context in the waterway sector is averse to change because of path dependencies. Waterway renewal, therefore, requires actors to navigate between institutional reproduction
Woltjer, Johan, Busscher, Tim, Arts, J., Woltjer, J, Busscher, T, Arts, J. (Janine), Busscher, Tim; id_orcid, Busscher, T., Woltjer, J., Willems, J.J., Arts, Jos, Arts, Jos; id_orcid, Willems, Jannes J., Woltjer, Johan; id_orcid   +13 more
core   +2 more sources

Shocks, institutional change, and sustainability transitions. [PDF]

Proc Natl Acad Sci U S A, 2023
Johnstone P, Schot J.
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Meaningful public involvement: changing research institutions toward epistemic justice

Frontiers in Public Health
Public and patient involvement and engagement (PPIE) in research is increasingly expected and often formally required by the sponsors. However, creating and sustaining conditions for meaningful PPIE can be challenging. It requires efforts of all involved
Tomasz Krawczyk, Tomasz Krawczyk, Tomasz Krawczyk, Jan Piasecki, Jacqueline Galica, Jacqueline Galica, Marcin Waligora, Marcin Waligora   +7 more
doaj   +1 more source

The Conditions for Functional Mechanisms of Compensation and Reward for Environmental Services

Ecology and Society, 2010
Mechanisms of compensation and reward for environmental services (CRES) are becoming increasingly contemplated as means for managing human-environment interactions.
Brent M. Swallow, Beria Leimona, Thomas Yatich, Sandra J. Velarde   +3 more
doaj   +1 more source

Community engagement and financial arrangements: Navigating institutional change. [PDF]

J Clin Transl Sci, 2023
Sprague Martinez L, Howard RC, Schotland M, Lobb R, Battaglia T, Stone S, Auerswald C, Ozer E.   +7 more
europepmc   +1 more source