Results 101 to 110 of about 2,324,008 (310)

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Interests versus culture in the theory of institutional change? [PDF]

This paper suggests an analytical framework to bring two explanations of institutional change together. My analysis rests on three building blocks: Firstly on the idea of the transfer or transplantation of institutions, secondly on the idea of functional
Zweynert, Joachim
core  

The biomedical informatics short course at Woods Hole/Georgia: Training to support institutional change. [PDF]

Inf Serv Use, 2022
Cimino JJ.
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Institutional Barriers to Digital Governance in Ecuador: Evidence from the Fourth Industrial Revolution

Revista Española de la Transparencia
This study analyzes the institutional challenges hindering the digital transformation of the public sector in Ecuador, within the context of the Fourth Industrial Revolution.
Raquel Vera Ortega, Linda Yong Amaya
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

A framework for institutional analysis

, 1999
Includes bibliographical references. Cover title: Societal and Institutional Responses to Climate Change and Cliamtic Hazards : managing flood and drought risk (SIRCH) : a framework for institutional analysisAvailable from British Library Document Supply
University of Oxford. Environmental Change Unit (United Kingdom), Bakker, Karen, Societal and Institutional Responses to Climate Change and Climatic Hazards ( Project) (United Kingdom)   +2 more
core  

Section Editorial: Supporting institutional change

Journal of Learning Development in Higher Education, 2021
Cathy Malone
doaj   +1 more source

The impact of socio-economic institutional change on agricultural carbon dioxide emission reduction in China. [PDF]

PLoS One, 2021
Long DJ, Tang L.
europepmc   +1 more source