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Contemporary Research on Agency in Education: A Systematization of Key Concepts and Developments

Вопросы образования
The task of developing individual "agency" (autonomy, proactivity, initiative, etc.), in education is widely discussed in scientific and practical circles.
Pavel S. Sorokin, Timofey D. Redko
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Educational Policy Development as a Leadership Experience: Inclusive Institutional Change. [PDF]

Med Sci Educ, 2023
Cheema A, Morris L, Suresh A, Carhart B, Thomson C, Synan L, Sorensen MJ, Chimienti SN.   +7 more
europepmc   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Meaningful public involvement: changing research institutions toward epistemic justice

Frontiers in Public Health
Public and patient involvement and engagement (PPIE) in research is increasingly expected and often formally required by the sponsors. However, creating and sustaining conditions for meaningful PPIE can be challenging. It requires efforts of all involved
Tomasz Krawczyk, Tomasz Krawczyk, Tomasz Krawczyk, Jan Piasecki, Jacqueline Galica, Jacqueline Galica, Marcin Waligora, Marcin Waligora   +7 more
doaj   +1 more source

The Conditions for Functional Mechanisms of Compensation and Reward for Environmental Services

Ecology and Society, 2010
Mechanisms of compensation and reward for environmental services (CRES) are becoming increasingly contemplated as means for managing human-environment interactions.
Brent M. Swallow, Beria Leimona, Thomas Yatich, Sandra J. Velarde   +3 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Valuing adaptation under rapid change [PDF]

, 2013
The methods used to plan adaptation to climate change have been heavily influenced by scientific narratives of gradual change and economic narratives of marginal adjustments to that change.
Celeste Young, John Handmer, Roger N Jones   +2 more
core  

“We ensure that children and young people have a place to be and something meaningful to do”. Sustainable development in the Norwegian riding schools

Frontiers in Sports and Active Living
Sport plays a significant role in promoting sustainable development at both local and global levels. However, many sports struggle to meet sustainability demands. To foster change and make sport more sustainable, it is essential to understand the factors
Aage Radmann, Mathilde Kronborg, Anna Sätre, Petra Andersson, Gabriella Torell Palmquist, Susanna Hedenborg   +5 more
doaj   +1 more source

Power and resistance in schools: Implementing institutional change to promote health equity for sexual and gender minority youth. [PDF]

Front Health Serv, 2022
Shattuck D, Richard BO, Jaramillo ET, Byrd E, Willging CE.   +4 more
europepmc   +1 more source