Results 61 to 70 of about 17,325,720 (353)
Molecular Oncology, EarlyView.Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma +9 more
wiley +1 more source
Contracts and Induced Institutional Change
The Journal of Law, Economics, and Organization, 2016 Abstract We study agents’ incentives to form horizontal coalitions before a principal offers vertical contracts. When a vertical contract generates negative externalities on other agents, the agents may collude in order to obtain better deals; when one contract benefits other agents, the agents may decentralize, instead.
Harstad, Bård, Mideksa, Torben
openaire +5 more sources
Landscape of BRAF transcript variants in human cancer
Molecular Oncology, EarlyView.We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda +5 more
wiley +1 more source
Pressões da globalização e a resposta criadora
Cadernos EBAPE.BREste artigo aborda a globalização como um complexo processo de institucionalização e examina o potencial da teoria institucional na elucidação das características do fenômeno, em especial, na forma específica como se manifesta nas regiões periféricas ...
Luiz Alberto da Costa Mariz
doaj +1 more source
Resilience revisited: taking institutional theory seriously
Ecology and Society, 2015 Resilience thinking has in recent decades emerged as a key perspective within research and policy focusing on sustainable development and the global environmental challenges of today.
Martin Sjöstedt
doaj +1 more source
, 2016 This article proposes an explanation as to why institutional change – understood as more competences for the European Union's supranational institutions – has rarely led to policy change in the Area of Freedom, Security and Justice (AFSJ).
F. Trauner, Ariadna Ripoll Servent
semanticscholar +1 more source
Molecular Oncology, EarlyView.In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed +8 more
wiley +1 more source
Leading the church through institutional change
Scandinavian Journal for Leadership & TheologyWhile institutional changes in the religious landscape of Norwegian society have received much scholarly interest in recent decades, less attention has been paid to the agency provided by actors within the Church of Norway.
Helge Nylenna
doaj +1 more source
Molecular Oncology, EarlyView.Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho +11 more
wiley +1 more source