Results 71 to 80 of about 12,394,917 (338)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Within‐Plant Leaf Maturity and Trichome Density Variation Shape the Elemental Composition Divergence in Desert Plant Sand Rice (Agriophyllum squarrosum)

Ecology and Evolution
Subindividual variation in leaf elemental composition, driven by trichome density and leaf maturity, is critical for plant adaptation but poorly understood in desert species.
Ruilan Ran, Xiaoyun Cui, Xin Zhao, Yingxue Zhao, Caixia Zhang, Pengshan Zhao   +5 more
doaj   +1 more source

Institutional environment, technical executive power and agricultural enterprise innovation performance

Cogent Business & Management, 2020
The interaction between the organization and the institutional environment leads to organizational change or innovation. As the basic industry of China’s national economy, agricultural enterprises are transmitted from the institutional environment to the
Limei Cheng, Takyi Kwabena Nsiah, Kailun Sun, Ziyue Zhuang   +3 more
doaj   +1 more source

Methodical Ware of Evaluate the Economic Efficiency Institutional Changes in the Markets [PDF]

Журнал институциональных исследований, 2018
The article includes the solution of the question of methodical ware institutional changes research relating to different markets. Relying on the former suggested theoretical approach and the relevant modelling the article describes a set of techniques ...
Igor S. Pyzhev, Vadim P. Goryachev
doaj   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Institutional environment and bank capital ratios

Journal of Financial Stability, 2019
We investigate the influence of the institutional environment on bank capital ratios. Using a sample of 149 banks operating in the Middle East and North Africa region for the period 2004 to 2014, we find that, when stock markets have little presence ...
Tammuz H. Alraheb, Christina Nicolas, Amine Tarazi   +2 more
semanticscholar   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Managers’ Short-sightedness, Institutional Environment and Financing Risks

International Journal of Advanced Business Studies
Managers’ shortsightedness is an important factor affecting the company’s investment decision-making, and the stability of the institutional environment is an important factor affecting managers’ shortsightedness investment management. The article takes
Ruyue Xu, Benjamin Yin Fah Chan
doaj   +1 more source