Results 81 to 90 of about 12,394,917 (338)
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Efficient social policies with higher expenditure: an analysis for European countries [PDF]
, 2018 Based on the construction of two indicators to assess the relative effectiveness and efficiency of European welfare policies, we show that the variability of efficiency cannot be explained only by the amount of resources devoted to social policies but
Antonelli, MARIA ALESSANDRA +1 more
core
Implementation and design of a service-based framework to integrate personal and institutional learning environments [PDF]
, 2014 The landscape of teaching and learning has changed in recent years because of the application of Information and Communications technology. Among the most representative innovations in this regard are Learning Management Systems.
Alier Forment, Marc +4 more
core +2 more sources
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Big Governance Research: Institutional Constraints, the Validity Gap and BIM
, 2008 The pressing questions about governance today require research on a scale, and of a complexity, that the existing institutional environment for research has great difficulty supporting.
Acharya, Arnab, Houtzager, Peter P
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Institutional economics and the environment [PDF]
, 2012 [From text] What is Institutional Economics? Before delving into the concept of institutional economics, it will be useful to explain what is meant by institutions because institutions in economics have a particular meaning. The most commonly agreed upon
Fraser, Gavin
core +1 more source
Identifying and Ranking Environmental Factors Affecting the Settlement of Operational Budgeting in Iran [PDF]
حسابداری سلامت, 2013 Introduction: In Iran, the reform of budgeting system has been undertaken by Management and Planning Organization (currently known as Presidential Deputy on Strategic Supervision) for more than 12 years.
Z. Hajiha, A. Salarvand
doaj
Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276
FEBS Open Bio, EarlyView.Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig +7 more
wiley +1 more source