Results 71 to 80 of about 206,206 (262)

Liver Stiffness Directs Intrahepatic Cholesterol Accumulation Through YAP/TAZ in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
Liver stiffness promotes intrahepatic cholesterol accumulation by repressing LXRα through YAP/TAZ activation. Stiff matrices impair cholesterol efflux in hepatocytes, while YAP/TAZ deletion restores LXRα activity and prevents cholesterol‐induced fibrosis.
Na Young Lee, Myeung Gi Choi, Ho Jae Ryu, Young Jin Min, Seon Min Kim, Yeonseok Chung, Bo Kyung Koo, Yun Pyo Kang, Won Kim, Ja Hyun Koo   +9 more
wiley   +1 more source

Academic Libraries can Expand Institutional Repository Holdings with Gold Open Access Publications Collected Through Web Scraping

Evidence Based Library and Information Practice
A Review of:  Clark, B. (2023). Proactive institutional repository collection development techniques: Archiving gold open access articles and metadata retrieved with web scraping. Journal of Library Administration, 63(6), 743–765.
Kristy Hancock
doaj   +1 more source

Expandable Nanocomposite Shape‐Memory Hemostat for the Treatment of Noncompressible Hemorrhage

Advanced Science, EarlyView.
A nanocomposite‐coated shape memory foam rapidly expands, accelerates clotting, and reduces blood loss in vivo. Its fast volumetric expansion and strong procoagulant activity make it a promising hemostat for treating deep, noncompressible hemorrhage.
Saptarshi Biswas, Sarah E. Miller, Shounak Roy, Jeevika Thazhaiselvam, Samantha Foster, Manivannan Sivaperuman Kalairaj, Sasha M. George, Yava Jones‐Hall, Staci J. Horn, Fred J. Clubb, Taylor H. Ware, Duncan J. Maitland, Akhilesh K. Gaharwar   +12 more
wiley   +1 more source

Institutional Repository Know-how of a decade in Managing Digital Assets

EPJ Web of Conferences, 2018
The advent of the Internet and the mushrooming of information in various digital formats have resulted in looking at the library and its services with newer perspectives for conserving and disseminating scholarly publications.
Meera B.M., Krishnamurthy S, Kaddipujar Manjunath   +2 more
doaj   +1 more source

Engineered Living Systems With Self‐Organizing Neural Networks: From Anatomy to Behavior and Gene Expression

Advanced Science, EarlyView.
Ectodermal tissue excised from Xenopus embryos self‐organizes into a three‐dimensional mucociliary organoid. Here, we generate a neural variant, termed neurobot, by implanting neural precursor cells. Neurobots develop mature neurons, adopt distinct morphologies, exhibit more complex motility, and respond differentially to neuroactive compounds. Imaging
Haleh Fotowat, Laurie O'Neill, Léo Pio‐Lopez, Megan M. Sperry, Patrick Erickson, Tiffany Lin, Michael Levin   +6 more
wiley   +1 more source

Individual DOI minting for Open Repository: a script for creating a DOI on demand for a DSpace repository

Journal of the Medical Library Association
Digital Object Identifiers (DOIs) are a key persistent identifier in the publishing landscape to ensure the discoverability and citation of research products. Minting DOIs can be a time-consuming task for repository librarians.
Catherine Tess Grynoch, Lisa Palmer
doaj   +1 more source

An Introduction of National Chengchi University Academic Hub

Tūzī yǔ dàng’àn xuékān, 2019
National Cheng-Chi University Academic Hub (NCCU AH) is established in 2017, this system exposes the research areas, publications and team research results of our teachers and researchers.
Chia-Cheng Chang, Zong-Lin You
doaj   +1 more source

Machine‐Learning Decomposition Identifies a Big Two Structure in Human Personality with Distinct Neurocognitive Profiles

Advanced Science, EarlyView.
Using machine learning on a mega‐scale global dataset (n = 1,336,840) reveals a robust personality trait architecture beyond the Big Five. A Big Two model, broadly capturing social engagement and internal mentation, defines a geometric space that links personality to neurocognitive profiles.
Kaixiang Zhuang, Ji Chen, Jinfeng Han, Wei Cheng, Jiang Qiu, Jianfeng Feng, Simon Eickhoff, Deniz Vatansever   +7 more
wiley   +1 more source

TTNPB Promotes Human Pluripotent Stem Cell‐to‐Neural Stem Cell Transition via Modulation of Chromatin Accessibility and the S‐(5′‐adenosyl)‐L‐homocysteine/Choline Metabolic Network

Advanced Science, EarlyView.
A retinoic acid receptor agonist, TTNPB, drives the efficient generation of advanced neural stem cells (ANSCs) from human pluripotent stem cells. TTNPB‐centered chromatin remodeling and metabolic reprogramming, promote neuroectoderm commitment. The resulting cells show robust neural potential and functional efficacy in a rat depression model.
Ruilin Du, Yudi Ren, Qiaoqiao Meng, Peng Wei, Ruyu Zhu, Junjie Bao, Ye Yang, Shuo Yan, Chaorong Yue, Xueying Zhu, Shuo Cao, Chunxia Hao, Wei Sun, Yongli Song, Xihe Li, Zhimin Wu, Siqin Bao, Yanglin Chen   +17 more
wiley   +1 more source

Building a Dataset Search for Institutions: Project Update

Publications, 2019
Most out-of-the-box institutional repository systems do not provide the workflows and metadata features required for research data. Consequently, many libraries now support two institutional repository systems—one for publications, and one for ...
Sara Mannheimer, Jason A. Clark, James Espeland, Kyle Hagerman   +3 more
doaj   +1 more source