Results 61 to 70 of about 10,197,536 (325)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

PENERAPAN METODE PENELITIAN DAN PENGEMBANGAN DALAM MERANCANG SISTEM REPOSITORI INSTITUSI DI PERPUSTAKAAN

open access: yesJurnal Pustaka Ilmiah, 2019
Various research methods can be used in library development efforts, especially in designing and building institutional repository systems. In this paper, the literature review is focused on research and development methods to build and develop ...
Ahmad Jamaluddin Jufri
doaj   +1 more source

Development Analysis of Institutional Repository Website In the West Nusa Tenggara: Webometrics Study

open access: yesKhizanah al-Hikmah, 2023
The global proliferation of institutional repositories has garnered significant attention, particularly from research-intensive institutions. This trend is crucial for effectively storing, disseminating, and providing access to copious research and ...
Ridwan
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Institutional Repositories, Open Source Options, and Libraries [PDF]

open access: yes, 2008
This paper examines the purposes of institutional digital repositories and the development options that are available via open source software. Preservation of an institution's digital output is valuable to the submitting authors and the institution ...
Amaral, Megan E.
core  

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

open access: yesFEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee   +3 more
wiley   +1 more source

Institutional Repositories in India [PDF]

open access: yes, 2009
Institutional Repository (IR) disseminates rich source of digitized materials drafted and published by learned societies. In India major R& D institutes and few Academic Institutes provide an Institutional Repository (IR) service to its clientele.
Ashok Kumar, N.
core  

U.S. Repository Network: Moving from Vision to Action [PDF]

open access: yes, 2022
The U.S. Repository Network is an initiative of SPARC with support from the Confederation of Open Access Repositories (COAR). In its “Modernizing the Global Repository Network Initiative,” COAR identified the need for assistance in breaking down ...
Baich, Tina
core   +2 more sources

Perception and Information Behaviour of Institutional Repository End-Users Provides Valuable Insight for Future Development

open access: yesEvidence Based Library and Information Practice, 2012
Objective – To determine the perceptions and information behavior of institutional repository (IR) end-users. Design – Semi-structured interviews. Setting – The interviews were conducted over the telephone. Subjects – Twenty end-users of
Lisa Shen
doaj   +1 more source

Institutional Repositories and the Institution's Repository: What Is the Role of University Archives with an Institution's On-line Digital Repository?

open access: yesArchival Issues, 2004
Many college and university libraries have recently begun implementing or experimenting with "institutional repositories" and other on-line digital repositories that allow for the centralized management and sharing of locally produced electronic publications and records. This article reviews some of the literature advocating that libraries implement on-
openaire   +1 more source

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