Results 71 to 80 of about 49,482,926 (251)
Institutional Data Repository Development, a Moving Target
Code4Lib Journal, 2021 At the end of 2019, the Research Data Service (RDS) at the University of Illinois at Urbana-Champaign (UIUC) completed its fifth year as a campus-wide service.
Colleen Fallaw +4 more
doaj
Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity
Advanced Science, EarlyView.This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj +25 more
wiley +1 more source
Automated Extraction of Multicomponent Alloy Data Using Large Language Models for Sustainable Design
Advanced Science, EarlyView.A large language model (LLM) based pipeline is developed to automatically extract a comprehensive and accurate multicomponent alloy database from literature corpus. The extracted dataset is integrated with sustainability indicators to identify potential alloys that outperform existing industrial benchmark materials in terms of both performance and ...
Aravindan Kamatchi Sundaram +4 more
wiley +1 more source
Advanced Science, EarlyView.Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries +25 more
wiley +1 more source
F7 Drives Gastric Cancer Metastasis Through Anoikis Resistance and Tumor Microenvironment Remodeling
Advanced Science, EarlyView.ABSTRACT Coagulation factor VII (F7) has been implicated in tumor progression; however, its role in gastric cancer metastasis and immune evasion remains incompletely understood. In this study, we identified F7 as a clinically relevant driver of gastric cancer.
Lei Gao +9 more
wiley +1 more source
Advanced Science, EarlyView.Androgen receptor (AR) drives copper accumulation in prostate cancer while inducing MTF1 to buffer copper toxicity. EP300‐mediated lactylation of MTF1 at K218 promotes its nuclear translocation and metallothionein expression, sequestering cytosolic copper and preventing mitochondrial cuproptosis.
Kai Li +21 more
wiley +1 more source
Institutional Repository Know-how of a decade in Managing Digital Assets
EPJ Web of Conferences, 2018 The advent of the Internet and the mushrooming of information in various digital formats have resulted in looking at the library and its services with newer perspectives for conserving and disseminating scholarly publications.
Meera B.M. +2 more
doaj +1 more source
An Introduction of National Chengchi University Academic Hub
Tūzī yǔ dàng’àn xuékān, 2019 National Cheng-Chi University Academic Hub (NCCU AH) is established in 2017, this system exposes the research areas, publications and team research results of our teachers and researchers.
Chia-Cheng Chang, Zong-Lin You
doaj +1 more source
Advanced Science, EarlyView.MetaboSense is a first‐of‐its‐kind microfluidic platform enabling continuous, in‐line monitoring of glucose and lactate during ex vivo lung perfusion. Combining a quantum dot–mediated aptamer assay with mixing, depletion, and optofluidic detection modules, it achieves 60–s temporal resolution and shows strong agreement with standard blood gas analyzers,
Sanjana Srikant +14 more
wiley +1 more source
Yeshiva Academic Institutional Repository (YAIR)
, 2020 Blog postIn May 2018, Yeshiva University Libraries launched the Yeshiva Academic Institutional Repository, otherwise known as YAIR, the official institutional repository, of Yeshiva University, created as part of the strategic plan drawn up to guide YU’s
Gross, Stephanie
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