Results 61 to 70 of about 2,232,854 (299)

Atlantic trade and regional specialisation in nothern Spain 1550-1650: an integrated trade theory-institutional organisation approach [PDF]

open access: yes, 2001
Based on an in-depth study of the northern Spanish economy in the sixteenth and seventeenth centuries, this paper argues that commercial expansion was a major source of the diverging performance of European regions.
Grafe, Regina
core   +2 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

University governance and academic research : case studies of research units in Dutch and English universities [PDF]

open access: yes, 2007
The central research question of our study addresses the effects of governing models on the research practices of basic research units in public universities in the fields of medieval history and biotechnology.
Leisyte, Liudvika
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

TOURISM EMPLOYMENT AND ENTREPRENEURSHIP DYNAMICS IN WILDLIFE DESTINATIONS IN SOUTHERN AFRICA [PDF]

open access: yesRevista Română de Geografie Politică
This study takes on a micro-institutional perspective to examine tourism employment and entrepreneurship dynamics within a complex socio-political and environmental Transfrontier Conservation Area context, using three destinations across Botswana ...
Refiloe J. LEKGAU, Tembi M. TICHAAWA
doaj   +1 more source

Challenge of inclusive growth : global capitalization : institutional cost transferring and the economic of being poor = 包容性增長的挑戰: 全球資本化: 制度成本轉嫁與貧困經濟學

open access: yes, 2011
My empirical research started with China’s experiment of rural reform during the 1980s-90s. According to the principle of experiment, only through a process of incessant falsification can we approach the truth.
WEN, Tiejun
core  

Why is Voting Habit-Forming: Evidence from Sweden [PDF]

open access: yes, 2010
For decades, scholars of electoral behavior have noted persistence in individuals' turnout decisions and hypothesized that such persistence is the result of habit.
Melton, James
core  

Doctorateness: where should we look for evidence? [PDF]

open access: yes, 2017
This chapter considers the possibility of an “institutional theory of artistic research”. It proposes four distinct quadrants in which one might look for evidence for such a theory, which needs to have the capacity to accommodate the diverse positions on
Biggs, Michael
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

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