Results 71 to 80 of about 21,656,789 (288)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Institutional matrices and institutional changes [PDF]

This article represents a paper for the 5th International Symposium on Evolutionary Economics “Economic Transformation and Evolutionary Theory of J. Schumpeter” (Pushchino, Moscow region, Russia, 25-27 September, 2003).
Kirdina, Svetlana
core  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Interim Report of the Institutional Repository Policy Committee

, 2004
This is the Interim Report of the Institutional Repository Policy Committee dated 23 July 2004. Document includes the names of the Institutional Repository Policy Committee from 2003-2004.- Executive summary - Background and Perspective - Status of ...
Institutional Repository Policy Committee
core  

Understanding Entrepreneurship Through the Enrichment of Institutional Theory by Ethics

, 2015
[EN] This work offers a deeper evaluation of entrepreneurship through institutional theory understanding, in which the technical-economic sphere is not only complemented by a social perspective, but also structured and governed in an ethical manner ...
Alexis J. Bañón-Gomis, Bañón Gomis, Alexis Jacobo   +1 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

vSEMERA: pilot project assessing health profession students’ experiences in an international virtual research program

BMC Medical Education
Background The “Virtual Semester for Medical Research Aachen” (vSEMERA) is an international, interdisciplinary, virtual education program developed for health profession students.
Laura Bell, Eliana Lemos, Jan Krimphove, Stephanie Kaiser, Cristina Guerra-Giraldez, Martin Lemos   +5 more
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Sustainable Economic Development: Theory of Institutional Constructivism

Экономика: стратегия и практика
The paper is devoted to the formulation of the problem of sustainable development of the intellectual economy and the use of the theory of constructivism in relation to solving the problems of institutional design of socio-economic systems.
E. A. Naumov
doaj   +1 more source

TOURISM EMPLOYMENT AND ENTREPRENEURSHIP DYNAMICS IN WILDLIFE DESTINATIONS IN SOUTHERN AFRICA [PDF]

Revista Română de Geografie Politică
This study takes on a micro-institutional perspective to examine tourism employment and entrepreneurship dynamics within a complex socio-political and environmental Transfrontier Conservation Area context, using three destinations across Botswana ...
Refiloe J. LEKGAU, Tembi M. TICHAAWA
doaj   +1 more source