Results 61 to 70 of about 21,656,789 (288)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Entrepreneurial Business and Economics Review, 2019 Objective: The objective of this article is to investigate the use of internationalisation to “escape” the institutional voids present in conflict economic systems, through interviews with fifteen Afghan family business leaders who run ...
Muska Hanify +3 more
doaj +1 more source
Institutional Theories and Public Institutions: New Agendas and Appropriateness
, 2012 This chapter covers the evolution of institutional theory and its application to public adminsitrations in the last 20 years. It discusses the various streams, their reseach agendas and their contributions, but also their limits to add value to knowledge.
openaire +2 more sources
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Improvement and Public Service Relationships: Cultural Theory and Institutional Work [PDF]
, 2016 This article examines the influence of cultural-institutional factors on user–provider relationships in public services. Using Grid-Group Cultural Theory (CT) as a way to structure the complexity of public service relationships, the article ...
Simmons, Richard, RICHARD SIMMONS
core +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Speaking for human being: institutional logics, dragons, and the supra-human
Revista Eletrônica de Ciência AdministrativaThis essay engages with the mounting published criticism of neo-institutionalism, particularly the institutional logical approach. By addressing each of the main critiques formulated by the opponents of the theory – (1) institutional logical theory is ...
Roger Friedland, Diane-Laure Arjaliès
doaj +1 more source
Institutional differences in CEO sustainability messages: Text mining of Korean and global firms’ reports [PDF]
Problems and Perspectives in ManagementType of the article: Research Article AbstractSustainable management and corporate sustainability communication (CSC) have become central themes in both research and practice.
Tae-Il Yoon
doaj +1 more source
Literature Review of Enterprise Systems Research Using Institutional Theory: Towards a Conceptual Model [PDF]
This paper sets out to examine the use of institutional theory as a conceptually rich lens to study social issues of enterprise systems (ES) research. More precisely, the purpose is to categorize current ES research using institutional theory to develop ...
Svejvig, Per
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