Results 71 to 80 of about 2,232,854 (299)

vSEMERA: pilot project assessing health profession students’ experiences in an international virtual research program

BMC Medical Education
Background The “Virtual Semester for Medical Research Aachen” (vSEMERA) is an international, interdisciplinary, virtual education program developed for health profession students.
Laura Bell, Eliana Lemos, Jan Krimphove, Stephanie Kaiser, Cristina Guerra-Giraldez, Martin Lemos   +5 more
doaj   +1 more source

Communities of Scholars: A Conceptual Scheme of Knowledge Production

Societies, 2018
This conceptual paper provides a meta-theoretical synthesis describing knowledge production processes in the sociological discipline. The first part of this paper gives an overview of recent studies exploring the sociological knowledge space with an ...
Konstantinos Zougris
doaj   +1 more source

A needs theory of governance [PDF]

, 2016
New-institutional economics hypothesizes imperfect rationality, self-seeking preferences, monetary-related needs, and opportunism as fundamental features of human behavior.
Sacchetti, Silvia, Tortia, Ermanno
core  

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Sustainable Economic Development: Theory of Institutional Constructivism

Экономика: стратегия и практика
The paper is devoted to the formulation of the problem of sustainable development of the intellectual economy and the use of the theory of constructivism in relation to solving the problems of institutional design of socio-economic systems.
E. A. Naumov
doaj   +1 more source

Social and cultural origins of motivations to volunteer a comparison of university students in six countries [PDF]

, 2010
Although participation in volunteering and motivations to volunteer (MTV) have received substantial attention on the national level, particularly in the US, few studies have compared and explained these issues across cultural and political contexts. This
Anne Birgitta Pessi, Astin, A.W., Astin, A.W., Astin, A.W., Baum, F.C., Bozzo, S., Civicus, Crosby, O., Davis Smith, J., Devlin, R.A., Esping-Anderson, G., Femida Handy, Friedland, L., Gabard, D.L., Gillespie, D., Grönlund, H., Hall, M., Hall, M., Hall, M., Handy, F., Independent Sector, Jeffrey L. Brudney, Jones, F., Jones, F., Lesley Hustinx, Musick, M.A., Naoto Yamauchi, O’Brein, E.M., Ram A. Cnaan, Salamon, L.M., Salamon, L.M., Salamon, L.M., Salamon, L.M., Smith, E., Taniguchi, H., Tuan, Y., Volunteering in America, Wikipedia, Winniford, J.C., Wuthnow, R., Yamauchi, N., Yu-Ting C.M.   +41 more
core   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source