Results 31 to 40 of about 400,178 (259)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

GPTBot Development for Translation Purposes: Flowchart, Practical Case and Future Prospects

Journal of Language and Education
Background: This paper explores the development and evaluation of a GPTBot tailored for institutional translation tasks. It addresses a gap in applied research on how generative AI can be adapted for domain-specific translation workflows, particularly ...
Helena Ortiz-Garduño, Daniel Torres-Salinas   +1 more
doaj   +1 more source

Proposal to Improve Employability and Facilitate Entrepreneurship among Graduates of the Master’s Degree in Institutional Translation of the University of Alicante

Hermes, 2020
  The aim of this article is to describe the strategies included in our proposal to improve employability and facilitate entrepreneurship among graduates of the Master’s Degree in Institutional Translation.
Analía Cuadrado-Rey, Lucía Navarro-Brotons   +1 more
doaj   +1 more source

Discourse and Communication Translation Model and Translation Strategy: an Experimental Study

Научный диалог, 2021
A longitudinal mediated asynchronous procedural experimental study is presented, the purpose of which is to demonstrate the correlation between the discourse and communication translation model and the translation strategy.
T. A. Volkova
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Institutional memory and translating at the DGT

The Translator, 2016
This paper aims to explore notions of memory with a focus on ‘institutional memory’, and to illustrate how such concepts can be useful in the study of translation in relevant contexts. Following an explanation of the theoretical framework a case study is presented.
openaire   +3 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Metaphorical Framing in Political Translation: Translating Xi Jinping’s Ecological Progress

transLogos: Translation Studies Journal
Metaphors are intricate linguistic devices and potent cognitive-discursive tools for persuasion in both source texts (ST) and target texts (TT). They primarily function in framing, namely the selection and clarification of cognitive domains, a ...
Enci HUANG, Qijun SONG
doaj   +1 more source

Tłumaczenie prawa unijnego a centralne pojęcia przekładoznawstwa

Między Oryginałem a Przekładem, 2016
Translation of EU law versus the central concepts of Translation Studies The objective of the paper was: (1) to analyse EU translation in light of central concepts of Translation Studies, and (2) to attempt a synthesis of numerous studies on EU ...
Łucja Biel
doaj   +1 more source